Testing fast-ripple brain signals to guide epilepsy surgery planning
Tests special electrodes and fast-ripple brain signals in adults with hard-to-treat epilepsy.
Key facts
- Who runs it
- University Hospital, Toulouse
- Where
- Amiens, Bordeaux, La Tronche, Le Kremlin-Bicêtre, Lille, Lyon, Nancy, Paris, Rennes, Strasbourg, and Toulouse, FranceSee the 12 sites
- Trial code
- Registry title
- Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
- Status
- Recruiting
- People taking part
- 440 people, planned
- Started
- 19 Jan 2024
- Expected to end
- Apr 2030
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- DIXI Medical Microdeep® Micro- Macro Depth electrodes
- Standard electrodes
- Record updated
- 21 October 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 65 with epilepsy that does not respond to medicines and who are having SEEG (a brain recording test with electrodes placed in the brain) before possible surgery.
- Age
- 18 to 65 years
- Sex
- All sexes can join.
- Disease stage
- Drug-resistant focal epilepsy, as defined by the International League Against Epilepsy, with SEEG planned after a multidisciplinary epilepsy meeting.
Main reasons for not taking part
- Under legal protection (guardianship, curatorship or safeguard of justice)
- Deprived of liberty by a judicial or administrative decision
- Has a cardiac defibrillator
- In the exclusion period of another study
- Not covered by the French healthcare system
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Patient suffering from drug-resistant focal epilepsy (DRFE), as defined by the International League Against Epilepsy, undergoing SEEG, the indication of which was selected during a multidisciplinary epilepsy meeting
- Patient who has given written informed consent to allow the study data collection procedures
- Patient covered by the French healthcare system
Who cannot take part
- Patient with a cardiac defibrillator
- Patients under juridical protection (authorship, curators or safeguarding of justice)
- Patient deprived of liberty by a judicial or administrative decision
- Patient in exclusion period of another study
- No other non-inclusion criteria since the study will only be proposed to patients who already meet the criteria for a SEEG
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Where in France
- Chu Amiens PicardieAmiens, FranceContact: William SZURHAJTaking people
- University Hospital of BordeauxBordeaux, FranceContact: Véronique MICHELTaking people
- University hospital of Grenoble-AlpesLa Tronche, FranceContact: Philippe KAHANETaking people
- APHP Hôpital BicêtreLe Kremlin-Bicêtre, FranceContact: Delphine TAUSSIGTaking people
- CHU de LilleLille, FranceContact: Philippe DERAMBURETaking people
- Hospices Civils de LyonLyon, FranceContact: Sylvain RHEIMSTaking people
- CHRU de NancyNancy, FranceContact: Jacques JONASTaking people
- Fondation Adolphe de RothschildParis, FranceContact: Sinéad ZEIDANTaking people
- Hopital Pitie-SalpetriereParis, FranceContact: Vincent NAVARROTaking people
- CHU de RennesRennes, FranceContact: Dragos-Mihai MALIIATaking people
- Hopitaux Universitaires de StrasbourgStrasbourg, FranceContact: Edouard HIRSCHTaking people
- University Hospital of ToulouseToulouse, FranceContact: Luc VALTON, MDTaking people
About the trial
What the trial wants to find out
The main aim of this study is to evaluate the contribution of fast-ripples (FR) information on the neurosurgery management of patients with drug-refractory epilepsy investigated by Stereo-ElectroEncephaloGraphy (SEEG), as measured by freedom from disabling seizures one-year post-surgery.
Read full original descriptionShow less
220 patients (for whom 4-6 usual clinical macro-electrodes will be replaced by hybrid micro-macro electrodes and for whom fast-ripples will be assessed) distributed over 6 centres and 220 control patients(who will undergo an SEEG with the usual electrodes and for whom fast-ripples will not be assessed) distributed over 6 centres. This is a controlled, non-randomized, parallel plan, prospective, multicentre exploratory study.
The 2 groups in the trial
- Arm with fast-ripples informationTreatment being tested
Patients for whom 4-6 usual clinical macro-electrodes will be replaced by hybrid micro-macro electrodes and for whom fast-ripples will be assessed
Treatment: DIXI Medical Microdeep® Micro- Macro Depth electrodes
- Arm without fast-ripples informationExisting treatment, for comparison
Patients who will undergo an SEEG with the usual electrodes and for whom fast-ripples will not be assessed.
Treatment: Standard electrodes
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Contribution of Fast-ripples to the Improvement of the Neurosurgical Management of Drug-refractory Epilepsy
- Plain-language title
- Testing fast-ripple brain signals to guide epilepsy surgery planningGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06105645, who can take part
- Record updated
- 21 October 2026