Studying airway cells and mucus in people with and without asthma
Compares airway cells and mucus production in adults with and without asthma.
Plain-language title generated from the registry record
Registry title: Mechanistic Insights From Bronchoscopy Airway Samples
Key facts
- Where
- San Francisco, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT06105710, who can take part
Where in United States
- University of California San FranciscoSan Francisco, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of California, San Francisco
- Trial code
- NCT06105710
- Record updated
- 24 April 2026
- Original description
The purpose of this study is to examine the mechanisms of asthma. The investigators are comparing the cells of individuals with and without asthma and looking at the roles various parts of the cell play in the production and secretion of mucus.Read full original descriptionShow less
Mechanistic Insights From Bronchoscopy Airway Samples
The purpose of this study is to examine the mechanisms of asthma. The investigators are comparing the cells of individuals with and without asthma and looking at the roles various parts of the cell play in the production and secretion of mucus.
Inclusion: Healthy Controls; Male and female subjects between the ages of 18 and 70 years; Ability to provide written informed consent and ability to comply with the requirements of the study; No hyperreactivity to methacholine (PC20 FEV1 Methacholine >16 mg/mL); No history of allergic rhinitis/seasonal allergies; Asthmatics; Male and female subjects between the ages of 18 and 70 years; Ability to provide written informed consent and ability to comply with the requirements of the study; History of asthma; No use of oral or inhaled corticosteroids for the treatment of asthma during the past 6 weeks; Hyperreactivity to methacholine (PC20 FEV1 Methacholine < 8 mg/ml).
Exclusion: Subjects with a history of prior esophageal hernia surgery; Current participation in an investigational drug trial; Prohibited Medications and Treatments The following medications are prohibited during the study and must be discontinued prior to enrollment for the amount of time specified below; Steroids (oral, inhaled or nasal): 6 weeks; Omalizumab: 6 months; Medications to be withheld prior to bronchoscopy: Aspirin or Non- steroidal anti-inflammatory agents (NSAIDs) for 2 days Medications to be withheld before each clinic visit: Short-acting bronchodilators (e.g. Albuterol) for 6 hours; Short-acting anti- cholinergics (e.g. Atrovent, Combivent) for 8 hours; and antihistamines (e.g. Benadryl, Claritin) for 3 days; Subjects with a history of lung disease other than asthma; Subjects with a history of a medical disease, which in the opinion of the Investigator may put the subject at extra risk from study-related procedures or because the disease may influence the results of the study; Nedocromil sodium, sodium cromoglycate: 4 weeks; The same exclusion criteria will apply to both Sub-studies; Current smokers, defined by (a) >5 cigarettes smoked in past 12 months, and (b) ≤ 8 weeks since last time smoking; or former smokers who have a total smoking history; 10 pack-years; Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study; Astemizole: 12 weeks; Long-acting methylxantines: 2 days; Short-acting methylxantines: 12 hours; Montelukast: 7 days; Zafirlukast: 7 days; Salmeterol: 2 days.