MRI Scans Predicting Crohn's Relapse After Stopping Biologic Medicine
Studies whether bowel MRI scans predict Crohn's disease returning after biologic treatment stops.
Plain-language title generated from the registry record
Registry title: MRE Predictors of Disease Relapse After Stopping Biologics
Key facts
- Where
- London, United KingdomSee the site
Where in United Kingdom
- University College London HospitalLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University College, London
- Trial code
- NCT06124287
- Record updated
- 13 May 2024
- Original description
This study aims to investigate if MR Enterography (MRE) improves the ability to predict which Crohn's disease patients will relapse quickly (disease comes back) after stopping biologic medication. MRE is a safe MRI scan of the bowel, widely used in Crohn's disease patients.Read full original descriptionShow less
MR Enterography Predictors of Disease Relapse After Stopping Biologic Therapy in Crohn's Disease (METEOR).
This study aims to investigate if MR Enterography (MRE) improves the ability to predict which Crohn's disease patients will relapse quickly (disease comes back) after stopping biologic medication. MRE is a safe MRI scan of the bowel, widely used in Crohn's disease patients.
Inclusion: Luminal small bowel or colonic Crohn's disease in clinical remission; 16 years or older; MRE as part of routine care performed within three months prior, or one month after the decision to stop biologic therapy Anti-TNF (Adalimumab, infliximab, Certolizumab) IL-23 or IL-12 antagonists (Ustekinumab) Anti-integrin biologics (Natalizumab, Vedolizumab); Biologic therapy stopped due to clinical remission only; Definition of clinical remission: There is no agreed consensus on how clinical remission is defined and practice differs between hospitals and patients. To mirror current clinical practice, no strict definition of clinical remission will therefore be used. Detailed clinical parameters the time of stopping biologic agents will be collected.
Exclusion: Non-biological therapy, unless part of combination therapy with biologic agents; Biological therapy stopped for other reasons e.g. loss of effect, side effects; Resection of diseased segment(s) after MRE but before stopping biologic agent; <16 years of age; No MRE with the time window defined by eligibility criteria.