Tests several new medicines for long-term weight control in adults with obesity
Tests several investigational medicines for weight control in adults with obesity or overweight.
Plain-language title generated from the registry record
Registry title: A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
Key facts
- Where
- Amherst, Ammon, Austin, Chandler, Chicago, Cincinnati, City of Saint Peters, Dallas, Danville, East Syracuse, Fleming Island, Greenbrae, Greensboro, Greenville, Honolulu, Houston, Huntington Park, Las Vegas, Louisville, Miami, Miami Lakes, Monroe, Morehead City, Nashville, Needham, New Bedford, New Bern, New Port Richey, Orlando, Phoenix, Port Jefferson Station, Rochester, Rolling Hills Estates, San Antonio, Scottsdale, Skokie, Southfield, Springfield, Stamford, The Villages, Topeka, Troy, Tucson, Walnut Creek, Wenatchee, Weslaco, and West Des Moines, United StatesSee the 49 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT06143956, who can take part
Where in United States
- Dent Neurologic InstituteAmherst, United StatesTaking people
- Medical Research PartnersAmmon, United StatesTaking people
- IMA Clinical Research AustinAustin, United StatesTaking people
- The Institute for Liver Health II dba Arizona Clinical Trials - MesaChandler, United StatesTaking people
- Great Lakes Clinical Trials - RavenswoodChicago, United StatesNo longer taking part
- CTI Clinical Research CenterCincinnati, United StatesTaking people
- StudyMetrix ResearchCity of Saint Peters, United StatesTaking people
- FutureSearch Trials of DallasDallas, United StatesTaking people
- Velocity Clinical Research, DallasDallas, United StatesTaking people
- Sovah Clinical Research-River DistrictDanville, United StatesTaking people
- Velocity Clinical Research, SyracuseEast Syracuse, United StatesTaking people
- Northeast Research Institute (NERI)Fleming Island, United StatesNo longer taking part
- NorCal Medical Research, IncGreenbrae, United StatesTaking people
- Medication ManagementGreensboro, United StatesTaking people
- Tribe Clinical Research LLCGreenville, United StatesTaking people
- Pacific Diabetes & Endocrine CenterHonolulu, United StatesNo longer taking part
- PlanIt Research, PLLCHouston, United StatesTaking people
- Velocity Clinical Research-Huntington ParkHuntington Park, United StatesTaking people
- Las Vegas Medical ResearchLas Vegas, United StatesTaking people
- Monroe Biomedical Research - LouisvilleLouisville, United StatesTaking people
- New Horizon Research CenterMiami, United StatesTaking people
- Indago Research & Health Center, IncMiami Lakes, United StatesTaking people
- Monroe Biomedical ResearchMonroe, United StatesTaking people
- Lucas Research, Inc.Morehead City, United StatesTaking people
- Quality Medical ResearchNashville, United StatesTaking people
- KnownwellNeedham, United StatesTaking people
- Lucida Clinical TrialsNew Bedford, United StatesTaking people
- Lucas Research, Inc.New Bern, United StatesTaking people
- Suncoast Clinical Research, Inc.New Port Richey, United StatesTaking people
- Charter Research - Winter ParkOrlando, United StatesTaking people
- Hope Research InstitutePhoenix, United StatesNo longer taking part
- North Suffolk NeurologyPort Jefferson Station, United StatesNo longer taking part
- Rochester Clinical Research, LLCRochester, United StatesTaking people
- Peninsula Research AssociatesRolling Hills Estates, United StatesTaking people
- Endeavor Clinical TrialsSan Antonio, United StatesTaking people
- Tekton Research - Fredericksburg RoadSan Antonio, United StatesNo longer taking part
- Headlands Research - ScottsdaleScottsdale, United StatesTaking people
- NorthShore University Health SystemSkokie, United StatesNo longer taking part
- Headlands Research - DetroitSouthfield, United StatesTaking people
- Clinvest Headlands LLCSpringfield, United StatesTaking people
- Stamford Therapeutics ConsortiumStamford, United StatesTaking people
- Charter Research - Lady LakeThe Villages, United StatesTaking people
- Cotton O'Neil Diabetes & EndocrinologyTopeka, United StatesTaking people
- Arcturus Healthcare , PLC, Troy Internal Medicine Research DivisionTroy, United StatesTaking people
- The Institute for Liver Health II dba Arizona Liver Health-TucsonTucson, United StatesTaking people
- Diablo Clinical Research, Inc.Walnut Creek, United StatesTaking people
- Central Washington Health Services Association d/b/a Confluence HealthWenatchee, United StatesTaking people
- Texas Valley Clinical ResearchWeslaco, United StatesTaking people
- Iowa Diabetes and Endocrinology Research CenterWest Des Moines, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT06143956
- Record updated
- 7 October 2026
- Original description
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.Read full original descriptionShow less
A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Interventions for Chronic Weight Management in Adult Participants With Obesity or Overweight
The purpose of this Phase-2 chronic weight management master protocol (CWMM) is to create a framework to evaluate the safety and efficacy of various investigational interventions for chronic weight management with intervention-specific appendices (ISAs). The CWMM establishes entry criteria for newly enrolled participants across the master and the ISAs. The ISAs may start independently of other ISAs as interventions become available for clinical testing. The results for the CWMM screening record will be reported when all the ISA's complete.
Inclusion: Have a body mass index (BMI); ≥30 kilogram/square meter (kg/m²), or; ≥27 kg/m² and <30 kg/m², or with at least 1 weight-related comorbidity; Have had a stable body weight for the 3 months prior to randomization (<5%) body weight gain and/or loss.
Exclusion: Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening; Have any of the following cardiovascular conditions within 3 months prior to screening:; acute myocardial infarction; cerebrovascular accident (stroke); unstable angina, or; hospitalization due to congestive heart failure; Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma; Have poorly controlled hypertension; Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease; Have a history of symptomatic gallbladder disease within the past 2 years; Have a lifetime history of suicide attempts.