Tests losartan in adults with narrowed aorta after repair and high blood pressure
Tests losartan against placebo in adults with a repaired narrowed aorta and high blood pressure.
Plain-language title generated from the registry record
Registry title: A Study of Angiotensin-II Receptor Blocker on Cardiovascular Remodeling (VALUE Trial)
Key facts
- Where
- Rochester, United StatesSee the site
- Phase
- Phase 3
Where in United States
- Mayo Clinic in RochesterRochester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT06150560
- Record updated
- 11 September 2026
- Original description
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.Read full original descriptionShow less
A Phase III, Randomized, Double-Blind, Placebo Controlled Clinical Trial Evaluating the Benefits and Mechanism Of Action Of Angiotensin-II Receptor Blocker On Cardiovascular Remodeling In Patients With Repaired Coarctation Of Aorta
The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Inclusion: B/S1 hypertension; SBP 100-139 average based on 3 office measurements; Age 18 or Older; Previous COA Repair.
Exclusion: Currently on beta blocker (BB) therapy; Received antihypertensive medications within the past year; eGFR<30; Hyperkalemia (serum potassium >5.5mmol/L); Pregnancy/lactating; Severe Aortic or Mitral valve stenosis or regurgitation; Epicardial CAD diagnosis.