Glucose Control and Bone Health in Adults With Type 1 Diabetes
Studies bone markers in adults with type 1 diabetes after starting an automated insulin system.
Plain-language title generated from the registry record
Registry title: Glycemic Control and Osteohealth in Adults Living With Type 1 Diabetes
Key facts
- Where
- Montreal, CanadaSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with type 1 diabetes whose blood sugar is high and who plan to start an automated insulin delivery system. It studies whether better sugar control helps bone health.
- Age
- 18 to 100 years
- Sex
- All sexes
- Disease stage
- Type 1 diabetes or latent autoimmune diabetes of adults (LADA) for at least one year, with current HbA1c >8.0% (64 mmol/mol) and high sugar variability (CV >36.0% (370 mmol/mol) on CGM).
- Earlier treatment
- Must plan to start one of the commercially available automated insulin delivery (AID) systems and expect to use closed-loop mode. Must not have taken drugs that affect bone turnover markers in the past 12 months, such as oral or intra-articular glucocorticoids at the stated doses, aromatase inhibitors, anti-androgen therapy, anticoagulants, SGLT-2 inhibitors, thiazolidinediones or anti-osteoporosis drugs.
- Biomarker or test result
- HbA1c >8.0% (64 mmol/mol) and CV >36.0% (370 mmol/mol) on CGM. Must be willing to share CGM data.
Main reasons for not taking part
- Pregnant, gave birth or breastfed less than 6 months before the start, or plans pregnancy during the study
- Conditions affecting bone turnover markers, such as chronic kidney disease (eGFR <30 ml/min), liver disease, celiac disease, organ transplant, active cancer or rheumatoid arthritis
- Hormone gland diseases such as active hyperthyroidism, parathyroid disease, hypogonadism, Cushing syndrome or acromegaly
- Expected change in CGM sensor, insulin pump or AID during the study
- Current or expected use of hydroxyurea, or acetaminophen above 1g every 6 hours
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 100 years old?
Source: NCT06158503, who can take part
Where in Canada
- Centre Hospitalier de l'Université de MontréalMontreal, CanadaTaking people
- CHUMMontreal, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre hospitalier de l'Université de Montréal (CHUM)
- Trial code
- NCT06158503
- Record updated
- 25 February 2025
- Original description
Bone damage is frequently observed in type 1 diabetes, and hyperglycemia is associated with an increased risk of fracture. This pilot study in 25 people living with type 1 diabetes aims to determine whether the introduction of an automated insulin delivery (AID) system improves bone markers through rapide optimization of glycemic control. Measurements will be taken before the start of AID, 2 months and 4 months afterwards.Read full original descriptionShow less
GLYcemic COntrol and OSTEOhealth: Impact of Short-Term Glycemic Control on Skeletal Outcomes in Adults With Type 1 Diabetes
Bone damage is frequently observed in type 1 diabetes, and hyperglycemia is associated with an increased risk of fracture. This pilot study in 25 people living with type 1 diabetes aims to determine whether the introduction of an automated insulin delivery (AID) system improves bone markers through rapide optimization of glycemic control. Measurements will be taken before the start of AID, 2 months and 4 months afterwards.
Inclusion: Age ≥ 18 years; Diagnosis of T1D or latent autoimmune diabetes of adults (LADA) for at least one year; Current HbA1c >8.0% and high glycemic variability (CV >36.0% using CGM); Participant planning to start using one of the commercially available AID; Anticipated use of the closed-loop mode; Willing to share CGM data during the study period.
Exclusion: Woman who was pregnant, gave birth or breastfed less than 6 months before the beginning of the study or who plans to become pregnant during the study; Intake in the past 12 months of drugs influencing bone turnover markers, such as oral or intra-articular glucocorticoids (≥ 7.5 mg daily Prednisone or equivalent during ≥ 3 months or ≥ four intra-articular glucocorticoid infiltrations in the past year), aromatase inhibitor therapy for breast cancer and anti-androgen therapy for prostate cancer, anticoagulants, SGLT-2 inhibitors, thiazolidinediones, and anti-osteoporosis drugs; Conditions affecting bone turnover markers, such as chronic kidney disease (estimated GFR <30 ml/min), liver disease, intestinal malabsorption including celiac disease, organ transplant, active cancer, rheumatoid arthritis, and endocrinopathies (active hyperthyroidism, uncontrolled hypothyroidism with abnormal TSH, parathyroid disease, hypogonadism, Cushing syndrome, adrenal insufficiency and acromegaly); Anticipated therapeutic change and/or type of CGM sensor, insulin pump, or AID during the study period; Anticipated need to use acetaminophen during the study period at a dose above 1g every 6 hours; Current or anticipated use of hydroxyurea; Unable to consent.