Studies hormone changes after a meal in people with cystic fibrosis
Looks at how hormones respond to a mixed meal in adults with cystic fibrosis.
Key facts
- Who runs it
- University of Cincinnati
- Where
- Cincinnati, United StatesSee the site
- Trial code
- Registry title
- Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis
- Status
- Recruiting
- People taking part
- 61 people, planned
- Started
- 28 Mar 2023
- Planned end
- 1 Nov 2026
- Type of study
- Observational, 4 groups
- Treatments tested
- Mixed meal
- Record updated
- 25 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 45 with cystic fibrosis who take highly effective CFTR modulator therapy. It studies hormone changes after a mixed meal.
- Age
- 18 to 45 years
- Sex
- Men and women can join.
- Disease stage
- Diagnosed with cystic fibrosis. People with and without cystic fibrosis related diabetes are mentioned in the record.
- Earlier treatment
- Must be receiving highly effective CFTR modulator therapy. Must not be using systemic glucocorticoids.
Main reasons for not taking part
- Transplant recipient
- Lung function drop or flare-up within the last 3 months
- Use of systemic glucocorticoids
- Pregnancy
- Any prior diabetic ketoacidosis
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Diagnosed with cystic fibrosis
- Aged 18 to 45 years
- Males and females of any race and ethnicity
- Receiving highly effective CFTR modular therapy
Who cannot take part
- Transplant recipient
- Any prior history of diabetic ketoacidosis
- Known liver disease that would be expected to significantly impact metabolic variable as interpreted by a study doctor
- The presence of any other disease or condition, as interpreted by any one of the study doctors, that would be expected to confound the responses to liquid mixed meal or make participation in the study dangerous to the individual
- Acute lung function decline or exacerbation within the last 3 months
- Use of systemic glucocorticoids
- Pregnancy
- People who are cognitively impaired
- People who do not speak English
- For CFRD patients, a daily insulin requirement that exceeds 0.8 U/kg/day
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Where in United States
- University of CincinnatiCincinnati, United StatesContact: Jason Winnick, PhDTaking people
About the trial
What the trial wants to find out
In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this population.
The 4 groups in the trial
- Healthy controls
No cystic fibrosis (CF)
Treatment: Mixed meal
- Pancreatic sufficient CF
cystic fibrosis, but not pancreatic insufficient
Treatment: Mixed meal
- Pancreatic insufficient CF
cystic fibrosis and pancreatic insufficient
Treatment: Mixed meal
- CF-related diabetes
cystic fibrosis and diabetes
Treatment: Mixed meal
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Changes in Postprandial Hormone Levels in Cystic Fibrosis Related Diabetes.
- Plain-language title
- Studies hormone changes after a meal in people with cystic fibrosisGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06163482, who can take part
- Record updated
- 25 August 2026