Balloon Widening With Platelet Injection for Narrowed Colon in Crohn's Disease
Tests balloon widening plus platelet-rich plasma injection in adults with narrowed colon from Crohn's disease.
Plain-language title generated from the registry record
Registry title: Endoscopic Balloon Dilatation Combined With PRP Injection in Colonic Stenosis in Crohn's Disease
Key facts
- Where
- Guangzhou, ChinaSee the site
Where in China
- The Sixth Affiliated Hospital, Sun Yat-sen UniversityGuangzhou, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sixth Affiliated Hospital, Sun Yat-sen University
- Trial code
- NCT06165289
- Record updated
- 14 January 2026
- Original description
The aim was to investigate whether endoscopic balloon dilatation combined with PRP injection can help prevent or prolong restenosis in patients with Crohn's disease with colonic stenosis, and to explore the concentration of PRP. The study was a single-center, randomized, non-controlled study. Experimental group of patients underwent endoscopic balloon dilation and submucosal injection of PRP at the wound edge, historical control was used, and the patients included in the study were randomly divided into high concentration group and low concentration group.Read full original descriptionShow less
Efficacy and Safety of Endoscopic Balloon Dilatation Combined With Autologous Platelet-rich Plasma (PRP) Injection in Colonic Stenosis in Crohn's Disease
The aim was to investigate whether endoscopic balloon dilatation combined with PRP injection can help prevent or prolong restenosis in patients with Crohn's disease with colonic stenosis, and to explore the concentration of PRP. The study was a single-center, randomized, non-controlled study. Experimental group of patients underwent endoscopic balloon dilation and submucosal injection of PRP at the wound edge, historical control was used, and the patients included in the study were randomly divided into high concentration group and low concentration group.
Inclusion: Diagnosed as CD; Stenosis of the colon was found during colonoscopy, and surgery was not considered for the time being; ③ Narrow length <5cm; ④ The patients agreed to undergo endoscopic balloon dilatation and voluntarily signed the informed consent to participate in this study, and were capable of complying with the agreement.
Exclusion: The patient has contraindications for endoscopic therapy, such as coagulation disorder, severe cardiopulmonary dysfunction, active bleeding, and inability to cooperate; Deep and large active ulcer was found in the stenosis; < 18 years old; Foreign patients; Patients with a history of malignant tumors, including melanoma (except local skin cancer); Pregnant or nursing patients; Patients who could not be followed at all nodes of the primary outcome indicator; Other diseases that researchers believe could put patients at risk; Other diseases that researchers believe could put patients at risk.