Tests extra sleep and its effect on blood fats in adults with overweight
Tests sleep extension in adults who sleep under 6.5 hours a night.
Key facts
- Who runs it
- University of Utah
- Where
- Salt Lake City, United StatesSee the site
- Trial code
- Registry title
- Effect of Sleep Extension on Ceramides in People With Overweight and Obesity
- Status
- Recruiting
- People taking part
- 70 people, planned
- Started
- 12 Feb 2024
- Expected to end
- May 2028
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Sleep Extension Intervention
- Record updated
- 5 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18-45 with overweight or obesity who usually sleep less than 6.5 hours a night. It tests whether sleeping longer changes blood ceramides and insulin sensitivity.
- Age
- 18-45 years old
- Sex
- Men and women, in equal numbers
- Disease stage
- Body mass index (BMI) of 27.5-34.9 kg/m2. Usual total sleep time under 6.5 hours per night for the past 6 months, as reported by the person.
- Earlier treatment
- Cannot be in a weight loss or physical activity program such as the Diabetes Prevention Program. Cannot use prescription drugs or substances known to affect sleep or glucose metabolism, or blood thinners (anticoagulants).
- Biomarker or test result
- Fasting plasma glucose must be below 126 mg/dL (7 mmol/L) and HbA1c below 6.5% (48 mmol/mol).
Main reasons for not taking part
- Diagnosed sleep disorder or major psychiatric illness
- Significant organ disease, such as heart or kidney disease
- Diagnosed diabetes, or fasting plasma glucose 126 mg/dL (7 mmol/L) or higher, or HbA1c 6.5% (48 mmol/mol) or higher
- Pregnant or nursing, going through menopause or after menopause
- Shift work now or within the last year, or currently smoking
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Age: 18-45 years old; equal numbers of men and women
- Body mass index (BMI): 27.5-34.9 kg/m2
- Sleep Habits: habitual self-reported average total sleep time (TST) <6.5 hours per night for prior 6 months
Who cannot take part
- Weight change: >10% of body weight over prior six months
- Clinically diagnosed sleep disorder or major psychiatric illness
- Evidence of significant organ dysfunction or disease (e.g., heart disease, kidney disease)
- Cancer that has been in remission less than 5 years
- Shift-work: current or history of within last year
- Current enrollment in weight loss or physical activity program like the Diabetes Prevention Program
- Clinically diagnosed diabetes or fasting plasma glucose ≥126 mg/dL or HbA1c ≥6.5%
- Use of prescription drugs or substances known to influence sleep or glucose metabolism, or anticoagulant medications
- Pregnant/nursing, experiencing menopause or post-menopausal
- Currently smoking
- Alcohol intake>14 drinks per week or >3 drinks per day
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Where in United States
- College of Health Research Complex--University of UtahSalt Lake City, United StatesContact: Christopher DepnerTaking people
About the trial
What the trial wants to find out
The overall goal is to determine how a sleep extension intervention (increasing time in bed) in individuals who maintain less than 6.5 hours sleep per night affects their plasma ceramides and insulin sensitivity. Participants will undergo a randomized controlled trial, with sleep extension (intervention) and healthy lifestyle (control) groups. The sleep extension is designed to increase participant's time in bed by 2 hours per night. Alternatively, the control group will receive basic health information (e.g., physical activity, goal setting, and nutrition when eating out).
The 2 groups in the trial
- Control GroupNo study treatment, for comparison
Provided with general health information on diet and physical activity.
- Intervention GroupTreatment being tested
Sleep extension-based intervention focused on increasing time in bed by 2 hours per night.
Treatment: Sleep Extension Intervention
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Biomarkers of Habitual Short Sleep and Related Cardiometabolic Risk
- Plain-language title
- Tests extra sleep and its effect on blood fats in adults with overweightGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06180837, who can take part
- Record updated
- 5 August 2026