Mapping Brain Networks in Children with Epilepsy Using Imaging
Compares new brain imaging methods with invasive recordings to locate seizure origins in children.
Plain-language title generated from the registry record
Registry title: Mapping Epileptic Networks Using Multimodal Imaging
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Necker-Enfants Malades HospitalParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Imagine Institute
- Trial code
- NCT06202976
- Record updated
- 17 April 2025
- Original description
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.Read full original descriptionShow less
Mapping Epileptic Networks Using Multimodal Imaging
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.
To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI).
It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery.
The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.
Inclusion: Be under 18 years of age on the day of inclusion; Present with one of the following forms of epilepsy:; refractory focal lesional epilepsy; rare non-lesional epilepsy; Present abnormalities (spikes) on the intercritical EEG; Have been selected by the "Epilepsy" multidisciplinary staff; In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup; Be affiliated to a health insurance scheme.
Exclusion: Have generalized epilepsy; Requiring general anesthesia for MRI; Require sedation specifically for research; Be deprived of liberty or under guardianship.