Taking people in United StatesPhase 3

Tests efruxifermin in adults with liver scarring from fatty liver disease

Tests efruxifermin against a placebo in adults with fatty liver disease and mild liver scarring.

Plain-language title generated from the registry record
Registry title: A Study Evaluating Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis

Key facts

Where: Amarillo, Atlanta, Aurora, Austin, Baltimore, Bastrop, Bellaire, Birmingham, Bradenton, Brandon, Brownsville, Buffalo, Chandler, Chapel Hill, Charleston, Charlotte, Chattanooga, Chicago, Chula Vista, Clarksville, Colorado Springs, Columbia, Columbus, Conway, Coronado, Corpus Christi, Covington, Dallas, Dayton, Denison, Doral, Dothan, Durham, Edinburg, Englewood, Escondido, Falls Church, Fayetteville, Flagstaff, Florham Park, Flowood, Folsom, Forney, Fort Myers, Fort Worth, Gainesville, Glen Burnie, Greenbelt, Hammond, Hermitage, Hershey, Hialeah Gardens, Houma, Houston, Indianapolis, Inglewood, Inverness, Jackson, Jacksonville, Jonesboro, Kansas City, La Mesa, Lady Lake, Lakewood Rch, Lancaster, Largo, Las Vegas, Lehigh Acres, Lewisville, Little Rock, Long Beach, Los Angeles, Louisville, Madison, Maitland, Manhasset, Margate, Marietta, Marrero, McAllen, Metairie, Miami, Miami Gardens, Miami Lakes, Morehead City, Naples, Nashville, New Bedford, New Bern, New Haven, New Orleans, New Port Richey, New York, Newport Beach, Newport News, Norfolk, North Little Rock, Novi, Ocala, Ogden, Orange, Orlando, Palm Springs, Pasadena, Pembroke Pines, Peoria, Philadelphia, Pittsburgh, Port Orange, Raleigh, Redwood City, Reno, Richmond, Ridgewood, Riverview, Roanoke, Rochester, Sacramento, Salt Lake City, San Antonio, San Diego, San Francisco, San Marcos, Sandy City, Santa Fe, Santa Maria, Sarasota, Seattle, Shreveport, Somers Point, South Bend, South Ogden, Southfield, Sparta, Spokane, Springboro, St Louis, Statesville, Suffolk, Summerville, Temple Terrace, Topeka, Tucson, Venice, Viera, Waco, Washington D.C., Webster, West Des Moines, West Monroe, West Palm Beach, Westlake, Weston, Wichita, Wichita Falls, Winter Park, Wyoming, Ypsilanti, and Zephyrhills, United StatesSee the 159 sites
Phase: Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 80 years old?

Source: NCT06215716, who can take part

Where in United States

AmarilloAmarillo, United StatesTaking people
AtlantaAtlanta, United StatesTaking people
AuroraAurora, United StatesTaking people
AustinAustin, United StatesTaking people
BaltimoreBaltimore, United StatesTaking people
BastropBastrop, United StatesTaking people
BellaireBellaire, United StatesTaking people
BirminghamBirmingham, United StatesTaking people
BradentonBradenton, United StatesTaking people
BrandonBrandon, United StatesTaking people
BrownsvilleBrownsville, United StatesTaking people
BuffaloBuffalo, United StatesTaking people
ChandlerChandler, United StatesTaking people
Chapel HillChapel Hill, United StatesTaking people
CharlestonCharleston, United StatesTaking people
CharlotteCharlotte, United StatesTaking people
ChattanoogaChattanooga, United StatesTaking people
ChicagoChicago, United StatesTaking people
Chula VistaChula Vista, United StatesNo longer taking part
ClarksvilleClarksville, United StatesTaking people
Colorado SpringsColorado Springs, United StatesTaking people
ColumbiaColumbia, United StatesTaking people
ColumbusColumbus, United StatesNo longer taking part
ConwayConway, United StatesNo longer taking part
CoronadoCoronado, United StatesTaking people
Corpus ChristiCorpus Christi, United StatesTaking people
CovingtonCovington, United StatesTaking people
DallasDallas, United StatesTaking people
DaytonDayton, United StatesTaking people
DenisonDenison, United StatesTaking people
DoralDoral, United StatesTaking people
DothanDothan, United StatesTaking people
DurhamDurham, United StatesTaking people
EdinburgEdinburg, United StatesTaking people
EnglewoodEnglewood, United StatesTaking people
EscondidoEscondido, United StatesTaking people
Falls ChurchFalls Church, United StatesNo longer taking part
FayettevilleFayetteville, United StatesTaking people
FlagstaffFlagstaff, United StatesNo longer taking part
Florham ParkFlorham Park, United StatesNo longer taking part
FlowoodFlowood, United StatesTaking people
FolsomFolsom, United StatesTaking people
ForneyForney, United StatesTaking people
Fort MyersFort Myers, United StatesTaking people
Fort WorthFort Worth, United StatesTaking people
GainesvilleGainesville, United StatesTaking people
Glen BurnieGlen Burnie, United StatesNo longer taking part
GreenbeltGreenbelt, United StatesNo longer taking part
HammondHammond, United StatesTaking people
HermitageHermitage, United StatesTaking people
HersheyHershey, United StatesTaking people
Hialeah GardensHialeah Gardens, United StatesTaking people
HoumaHouma, United StatesTaking people
HoustonHouston, United StatesTaking people
IndianapolisIndianapolis, United StatesTaking people
InglewoodInglewood, United StatesNo longer taking part
InvernessInverness, United StatesTaking people
JacksonJackson, United StatesTaking people
JacksonvilleJacksonville, United StatesTaking people
JonesboroJonesboro, United StatesNo longer taking part
Kansas CityKansas City, United StatesTaking people
La MesaLa Mesa, United StatesNo longer taking part
Lady LakeLady Lake, United StatesNo longer taking part
Lakewood RchLakewood Rch, United StatesTaking people
LancasterLancaster, United StatesNo longer taking part
LargoLargo, United StatesTaking people
Las VegasLas Vegas, United StatesTaking people
Lehigh AcresLehigh Acres, United StatesTaking people
LewisvilleLewisville, United StatesNo longer taking part
Little RockLittle Rock, United StatesTaking people
Long BeachLong Beach, United StatesTaking people
Los AngelesLos Angeles, United StatesNo longer taking part
LouisvilleLouisville, United StatesTaking people
MadisonMadison, United StatesTaking people
MaitlandMaitland, United StatesNo longer taking part
ManhassetManhasset, United StatesTaking people
MargateMargate, United StatesTaking people
MariettaMarietta, United StatesTaking people
MarreroMarrero, United StatesTaking people
McAllenMcAllen, United StatesNo longer taking part
MetairieMetairie, United StatesTaking people
MiamiMiami, United StatesTaking people
Miami GardensMiami Gardens, United StatesTaking people
Miami LakesMiami Lakes, United StatesTaking people
Morehead CityMorehead City, United StatesTaking people
NaplesNaples, United StatesTaking people
NashvilleNashville, United StatesTaking people
New BedfordNew Bedford, United StatesTaking people
New BernNew Bern, United StatesTaking people
New HavenNew Haven, United StatesTaking people
New OrleansNew Orleans, United StatesTaking people
New Port RicheyNew Port Richey, United StatesNo longer taking part
New YorkNew York, United StatesTaking people
Newport BeachNewport Beach, United StatesTaking people
Newport NewsNewport News, United StatesNo longer taking part
NorfolkNorfolk, United StatesTaking people
North Little RockNorth Little Rock, United StatesTaking people
NoviNovi, United StatesTaking people
OcalaOcala, United StatesTaking people
OgdenOgden, United StatesNo longer taking part
OrangeOrange, United StatesTaking people
OrlandoOrlando, United StatesTaking people
Palm SpringsPalm Springs, United StatesNo longer taking part
PasadenaPasadena, United StatesTaking people
Pembroke PinesPembroke Pines, United StatesTaking people
PeoriaPeoria, United StatesTaking people
PhiladelphiaPhiladelphia, United StatesTaking people
PittsburghPittsburgh, United StatesTaking people
Port OrangePort Orange, United StatesTaking people
RaleighRaleigh, United StatesTaking people
Redwood CityRedwood City, United StatesTaking people
RenoReno, United StatesTaking people
RichmondRichmond, United StatesTaking people
RidgewoodRidgewood, United StatesTaking people
RiverviewRiverview, United StatesTaking people
RoanokeRoanoke, United StatesTaking people
RochesterRochester, United StatesTaking people
SacramentoSacramento, United StatesTaking people
Salt Lake CitySalt Lake City, United StatesNo longer taking part
San AntonioSan Antonio, United StatesTaking people
San DiegoSan Diego, United StatesNo longer taking part
San FranciscoSan Francisco, United StatesTaking people
San MarcosSan Marcos, United StatesNo longer taking part
Sandy CitySandy City, United StatesTaking people
Santa FeSanta Fe, United StatesNo longer taking part
Santa MariaSanta Maria, United StatesTaking people
SarasotaSarasota, United StatesTaking people
SeattleSeattle, United StatesTaking people
ShreveportShreveport, United StatesTaking people
Somers PointSomers Point, United StatesTaking people
South BendSouth Bend, United StatesTaking people
South OgdenSouth Ogden, United StatesNo longer taking part
SouthfieldSouthfield, United StatesNo longer taking part
SpartaSparta, United StatesTaking people
SpokaneSpokane, United StatesTaking people
SpringboroSpringboro, United StatesTaking people
St LouisSt Louis, United StatesTaking people
StatesvilleStatesville, United StatesTaking people
SuffolkSuffolk, United StatesNo longer taking part
SummervilleSummerville, United StatesTaking people
Temple TerraceTemple Terrace, United StatesTaking people
TopekaTopeka, United StatesTaking people
TucsonTucson, United StatesTaking people
VeniceVenice, United StatesNo longer taking part
VieraViera, United StatesNo longer taking part
WacoWaco, United StatesTaking people
Washington D.C.Washington D.C., United StatesNo longer taking part
WebsterWebster, United StatesTaking people
West Des MoinesWest Des Moines, United StatesTaking people
West MonroeWest Monroe, United StatesTaking people
West Palm BeachWest Palm Beach, United StatesNo longer taking part
WestlakeWestlake, United StatesTaking people
WestonWeston, United StatesTaking people
WichitaWichita, United StatesNo longer taking part
Wichita FallsWichita Falls, United StatesTaking people
Winter ParkWinter Park, United StatesTaking people
WyomingWyoming, United StatesTaking people
YpsilantiYpsilanti, United StatesNo longer taking part
ZephyrhillsZephyrhills, United StatesTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Print a page for my doctor

Trial details

Who runs it: Akero Therapeutics, Inc
Trial code: NCT06215716
Record updated: 6 November 2026
Original description: This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with non-cirrhotic NASH/MASH and fibrosis stage 2 or 3 (F2 or F3).Read full original descriptionShow less
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Efruxifermin in Subjects With Non-Cirrhotic Nonalcoholic Steatohepatitis (NASH)/Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with non-cirrhotic NASH/MASH and fibrosis stage 2 or 3 (F2 or F3).
The study will enroll subjects in two cohorts for a total samples size of 1650 subjects.
Inclusion: Males and non-pregnant, non-lactating females between 18 - 80 years of age inclusive, based on the date of the screening visit; Previous history or presence of 2 out of 4 components of metabolic syndrome (obesity, dyslipidemia, elevated blood pressure, elevated fasting glucose) or type 2 diabetes; Cohort 1: Biopsy-proven NASH/MASH. Must have had a liver biopsy obtained ≤ 180 days prior to screening with fibrosis stage 2 or 3 and a non-alcoholic fatty liver disease (NAFLD) activity score (NAS) of ≥ 4 with at least a score of 1 in each of the following NAS components:; Steatosis (scored 0 to 3),; Ballooning degeneration (scored 0 to 2), and; Lobular inflammation (scored 0 to 3); Cohort 2: Biopsy-proven fibrosis stage 3. Must have had a liver biopsy obtained ≤ 180 days prior to screening. Subjects with NAS <4 may be enrolled and are not required to meet 1 point in each of the components of NAS.
Exclusion: Type 1 or uncontrolled Type 2 diabetes; Other inclusion and exclusion criteria may apply; Other causes of liver disease based on medical history and/or liver histology and/or central laboratory results; Presence of cirrhosis on liver biopsy (fibrosis stage 4).
ClinicalTrials.gov NCT06215716