Long Term Evaluation of Clinical and Radiologic Results on Femoro-patellar Joint After High Tibial Osteotomy
Key facts
- Who runs it
- Istituto Ortopedico Rizzoli
- Where
- Bologna, ItalySee the site
- Trial code
- Status
- Recruiting
- People taking part
- 50 people, planned
- Started
- 22 Oct 2020
- Expected to end
- Dec 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- X-rays: load bearing inferior limbs, lateral knee, axial patella
- Record updated
- 23 February 2026
Who can take part
- Age
- 18 years to 65 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Diagnosis of medial unicompartmental knee osteoarthritis (Outerbridge III-IV)
- Follow-up > 60 months
- Completeness of clinical and radiographic documentation
- Previous valgus osteotomy procedure (MOW-HTO or LCW-HTO)
- Age <65 years
Who cannot take part
- Patients with previous injuries affecting the involved lower limb
- Patients with prior traumatic, septic, and rheumatoid arthritis
- Patients with previous alterations of the patellofemoral joint
- Patients with confirmed neuromuscular disorders or psychomotor disturbances
- Patients with congenital generalized hypermobility syndrome
- Patients with knee ligament injuries
- Patients with severe pathologies in other organs or systems limiting activities of daily living (ADL)
- Patients who refuse to participate in the study
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Where in Italy
- IRCCS Istituto ortopedico RizzoliBologna, ItalyContact: Giulio Maria Marcheggiani Muccioli, MD, PhDTaking people
About the trial
What the trial wants to find out
Osteotomies are among the oldest orthopedic treatments, in use for over 2000 years and still commonly employed. The basic principle involves making a bone cut to allow the realignment of the limb segment affected by deformity. Today, new knowledge and technologies, understanding of bone healing mechanisms, and the introduction of new fixation methods have made osteotomies one of the preferred treatments for early knee arthritis. They serve as an alternative to joint prosthesis implantation in young patients with medium to high functional demand.
Read full original descriptionShow less
Medial knee osteoarthritis is a pathology increasingly prevalent in today's population. The resulting varus deformity leads to a shift in the load axis on the medial tibial plateau. Osteotomy in this context becomes a therapeutic tool capable of restoring the correct mechanical axis of the lower limb and delaying or avoiding the progression of arthritis, thus avoiding the need for joint replacement.
The two most commonly used techniques are the Closing Wedge Lateral High Tibial Osteotomy (LCW-HTO) and the Opening Wedge Medial High Tibial Osteotomy (MOW-HTO), which are high tibial osteotomies in closure with a wedge removal and in opening with a wedge insertion, respectively.
The medium to long-term effects of this procedure, in terms of survival and modification of the tibial slope, have been extensively studied, as evidenced by the extensive literature on the subject. However, the effect of this intervention, in its two variants, on the progression of femoro-patellar arthritis and the height of the patella remains poorly investigated to date.
The 2 groups in the trial
- Lateral closing wedge high tibial osteotomyExisting treatment, for comparison
Treatment: X-rays: load bearing inferior limbs, lateral knee, axial patella
- Medial opening wedge high tibial osteotomyExisting treatment, for comparison
Treatment: X-rays: load bearing inferior limbs, lateral knee, axial patella
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT06251752, who can take part
- Record updated
- 23 February 2026