Imaging Liver Cirrhosis With a PSMA Tracer and PET/MRI Scans
Tests a PSMA-based imaging tracer with PET/MRI to assess liver cirrhosis in adults.
Key facts
- Who runs it
- Massachusetts General Hospital
- Where
- Charlestown, United StatesSee the site
- Trial code
- Registry title
- Value of [68Ga]Ga-PSMA-11 PET/MRI in the Assessment of Liver Cirrhosis
- Status
- Recruiting
- People taking part
- 45 people, planned
- Started
- 10 Dec 2023
- Expected to end
- 19 Dec 2028
- Type of study
- Observational
- Treatments tested
- Injection of a gadolinium contrast agen
- Radiotracer Injection
- Imaging
- Record updated
- 14 October 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with liver cirrhosis. It uses a PET/MRI scan with a tracer called [68Ga]Ga-PSMA-11 to study the cirrhotic liver.
- Age
- From 18 to 99 years.
- Sex
- Men and women can join.
- Disease stage
- Liver cirrhosis diagnosed by imaging and/or clinical data, including pathology.
Main reasons for not taking part
- Any reason a person cannot have a PET scan
- Any reason a person cannot have an MRI scan
- Any reason a person cannot have gadolinium contrast, including gadolinium allergy
- Pregnancy or breast feeding
- Does not fit in the scanner: weight over 300 lbs (136 kg) or BMI over 33
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Liver cirrhosis as diagnosed by imaging and/or clinical data, including pathology
Who cannot take part
- Cumulative radiation exposure for research studies during the prior 12 months, combined with the exposure from this study, > 50 mSv
- Any contraindication to gadolinium-based contrast agent, including allergy to gadolinium, as in attached screening forms
- Any contraindication to PET, as in attached screening form
- Any contraindication to MRI, as in attached screening form
- Pregnancy
- Breast feeding
- Inability to fit in the scanner: weight > 300 lbs or BMI > 33
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Where in United States
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical SchoolCharlestown, United StatesContact: Onforio Catalano, MD, Ph.DTaking people
About the trial
What the trial wants to find out
A total of fifty-five (55) patients with liver cirrhosis will be enrolled in this study to produce and validate dedicated Ga-PSMA-PET/MRI acquisition protocols.
Read full original descriptionShow less
The specific hypotheses include:
* Ga-PSMA PET/MRI may allow robust and reproducible noninvasive in vivo quantitation of hepatic macro and microhemodynamics in cirrhotic patients * Dedicated simultaneously acquired DWI sequences might quantitate liver fibrosis and improve hemodynamic quantitation. * Ga-PSMA PET/MRI may allow noninvasive and reproducible quantitation of portal venous hypertension and predict its evolution, as well as response to treatments * Ga-PSMA PET/MRI may improve noninvasive and reproducible qualitative and quantitative assessment of liver function, structure, nodules and predict evolution of cirrhosis
The group in the trial
- Cirrhosis
55 Patients with liver cirrhosis
Treatment: Injection of a gadolinium contrast agen, Radiotracer Injection, and Imaging
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Technical Development and Clinical Validation of a Comprehensive One-stop Shop Assessment of the Cirrhotic Liver With [68Ga]Ga-PSMA-11 PET/MRI
- Plain-language title
- Imaging Liver Cirrhosis With a PSMA Tracer and PET/MRI ScansGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06265272, who can take part
- Record updated
- 14 October 2026