Tests nasal inflammation response to endotoxin in people with asthma
Tests a nasal endotoxin challenge in adults with asthma and healthy people.
Plain-language title generated from the registry record
Registry title: Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma
Key facts
- Where
- Denver, United StatesSee the site
- Phase
- Phase 1
Where in United States
- National Jewish HealthDenver, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Jewish Health
- Trial code
- NCT06270576
- Record updated
- 21 February 2024
- Original description
A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.Read full original descriptionShow less
Nasal Endotoxin Challenge to Study Mucosal Inflammation in Patients With Asthma
A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.
Inclusion: Participants will have asthma diagnosed by a health care provider. Healthy controls are individuals without asthma; Written informed consent.
Exclusion: Presence or prior history of cardiac or systemic disease; Current or recent illness (in the past 4 weeks); History of nasal perforation or nasal surgery; Bleeding disorder, use of systemic anticoagulants, or antiplatelet therapy; Immunocompromised state (HIV, immunoglobulin deficiency, systemic immunosuppressants excluding corticosteroids); Recent asthma exacerbation (past 4 weeks); Nasal polyposis; Use of tobacco or marijuana in the past 2 months or greater than a 10 pack-year smoking history; Currently pregnant or breastfeeding.