Preventing Return of Large Colon Polyps After Endoscopic Removal
Tests two heat-based techniques to treat the edges of large colon polyps after removal.
Plain-language title generated from the registry record
Registry title: Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Key facts
- Where
- Montreal, CanadaSee the site
Where in Canada
- Centre Hospitalier de l'Université de MontréalMontreal, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre hospitalier de l'Université de Montréal (CHUM)
- Trial code
- NCT06271941
- Record updated
- 18 September 2026
- Original description
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions.Read full original descriptionShow less
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions.
We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.
Inclusion: adult ≥18 years old; patients undergoing EMR for a large (≥20mm) colorectal LSL; patients providing written and informed consent for study participation.
Exclusion: inflammatory bowel disease; overt signs of deep submucosal invasive cancer (JNET 3); coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets <50 x 109/L); non-elective colonoscopy; poor general health (American Society of Anesthesiologists classification >III); pedunculated polyps (Paris class Ip, Isp); biopsy proven invasive carcinoma in a potential study polyp; Pregnant women.