Preventing Return of Large Colon Polyps After Endoscopic Removal
Tests two heat-based techniques to treat the edges of large colon polyps after removal.
Plain-language title generated from the registry record
Registry title: Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Key facts
- Where
- Montreal, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having an endoscopic removal (EMR) of a large flat colon or rectum polyp of 20mm or more. It compares two ways of treating the edges of the removal site.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- A large (20mm or more) laterally spreading polyp in the colon or rectum, removed by endoscopic mucosal resection (EMR)
Main reasons for not taking part
- Inflammatory bowel disease
- Colonoscopy that was not planned in advance
- Poor general health (American Society of Anesthesiologists class above III)
- Bleeding or clotting problems (international normalized ratio 1.5 or higher, or platelets below 50 x 109/L)
- Polyp on a stalk, signs of deep invasive cancer, or proven invasive cancer in the polyp
Read by machine on 12 November 2026.
Where in Canada
- Centre Hospitalier de l'Université de MontréalMontreal, CanadaContact: Julie FleuryTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Centre hospitalier de l'Université de Montréal (CHUM)
- Trial code
- NCT06271941
- Record updated
- 18 September 2026
- Original description
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions.Read full original descriptionShow less
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors. Such polyps have to be completely removed to prevent CRC and to avoid surgery and/or adjuvant therapy. The laterally spreading lesions (LSLs) are removed via endoscopic mucosal resection (EMR). However, recurrence is common. New techniques for LSL resection (hybrid argon plasma coagulation (h-APC) margin and base ablation) have shown a reduction in recurrence following the interventions.
We hypothesize that performing hybrid argon plasma coagulation (h-APC) margin and base ablation during EMR of large (≥20mm) colorectal LSLs will lead to lower rates of lesion recurrence compared to Snare tip soft coagulation (STSC) margin ablation.
Inclusion: adult ≥18 years old; patients undergoing EMR for a large (≥20mm) colorectal LSL; patients providing written and informed consent for study participation.
Exclusion: inflammatory bowel disease; overt signs of deep submucosal invasive cancer (JNET 3); coagulopathy or thrombocytopenia (international normalized ratio ≥1.5 or platelets <50 x 109/L); non-elective colonoscopy; poor general health (American Society of Anesthesiologists classification >III); pedunculated polyps (Paris class Ip, Isp); biopsy proven invasive carcinoma in a potential study polyp; Pregnant women.