Tests metformin in overweight adults with hard-to-control asthma
Tests metformin against a placebo in overweight or obese adults with poorly controlled asthma.
Plain-language title generated from the registry record
Registry title: Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Key facts
- Where
- Baltimore and Houston, United StatesSee the 2 sites
- Phase
- Phase 2
Where in United States
- Johns Hopkins UniversityBaltimore, United StatesTaking people
- Baylor College of MedicineHouston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johns Hopkins University
- Trial code
- NCT06273072
- Record updated
- 16 October 2026
- Original description
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.Read full original descriptionShow less
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
This is a randomized clinical trial of metformin among overweight or obese adults with not well-controlled asthma despite maintenance inhaler therapy.
Inclusion: Physician-diagnosed asthma on maintenance therapy; Not well-controlled asthma (ACT score <20, or at least one asthma exacerbation requiring corticosteroids in the prior 12 months); Overweight or obesity: Body mass index ≥25kg/m2; Adult: Age ≥18.
Exclusion: Taking Glucagon Like Peptide 1(GLP-1) medications for weight loss; Major cardiovascular disease: heart failure, heart attack or stroke within the last 6 months; Other chronic lung disease, inclusive of chronic obstructive pulmonary disease, bronchiectasis, interstitial lung disease, pulmonary fibrosis; Chronic kidney disease: estimated glomerular filtration rate ≤60 mL/min/1.73 m2; Liver disease: elevation in aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2x the upper limit of normal or prior diagnosis of liver disease; Anemia: hemoglobin < 13 g/dl in males and hemoglobin < 11 g/dl in females; Diabetes (Hemoglobin A1C ≥ 6.5% or taking metformin or other medications used to treat diabetes); Currently pregnant, expect to become pregnant in the next 6 months or are currently breastfeeding; Active smoking or former smoker with ≥20 pack-year smoking history; Heavy alcohol use: in a typical week, 8 or more drinks for a woman or 15 or more drinks for a man; Participation in any other clinical trial (observational studies are permitted).