Tracks bone strength growth in children with and without type 1 diabetes
Follows bone development in children aged 10 to 12 with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: Canadian Bone Strength Development Study
Key facts
- Where
- Saskatoon, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 12 years old?
Source: NCT06287840, who can take part
Where in Canada
- University of SaskatchewanSaskatoon, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Saskatchewan
- Trial code
- NCT06287840
- Record updated
- 6 March 2024
- Original description
The goal of this project is to learn about differences in bone development between children with and without type-1 diabetes (T1D). The main questions this study aims to answer are:Read full original descriptionShow less
Canadian Bone Strength Development in Children With Type 1 Diabetes Study
The goal of this project is to learn about differences in bone development between children with and without type-1 diabetes (T1D). The main questions this study aims to answer are:
1. Assess how and when sex-specific bone developmental trajectories in the leg and arm will differ between children with T1D and control cohorts relative to the critical period of rapid skeletal growth in puberty. It is hypothesized that children with T1D will have inferior bone development, particularly lower gains in bone strength. 2. Assess why bone trajectories differ between T1D and control cohorts by identifying the role of body composition, site-specific muscle force and physical activity on differences in bone properties in female and male children with and without T1D. It is hypothesized that children with T1D will have lower gains in lean mass, muscle force, number of daily bone impacts and minutes of moderate-vigorous physical activity and will be associated with inferior gains in bone development. 3. Assess why T1D may impair sex-specific bone development by exploring the role of disease-related factors (e.g., duration, glucose control, hormones and markers of bone turnover) and fracture history on bone trajectories of children with T1D. It is hypothesized that longer exposure to T1D, poorer glucose control, alterations in hormones, lower bone formation markers and higher history of fracture will be negatively associated with bone trajectories of children with T1D.
Participant's physical growth, bone growth, muscle strength, physical activity and nutrition habits will be assessed and followed up annually for up to 4 years.
Inclusion: Females: 10-11 years old; Males: 11 - 12 years old; Diagnosed with type-1 diabetes for at least 6 months; Capacity to give informed consent (patient and parent/guardian). Children with the capacity to give assent will do so in addition to parental consent; Females: 10-11 years old; Males: 11 - 12 years old; Capacity to give informed consent (patient and parent/guardian). Children with the capacity to give assent will do so in addition to parental consent.
Exclusion: Consuming any medications or have additional illnesses associated with bone health, osteoporosis (including renal disease, celiac disease, hypogonadism, hyperthyroidism) or altered physical growth (precocious puberty); Have an illness or are taking medications influencing bone health or physical growth; Have gone through adolescent growth spurt at study entry; Control Group (Typically Developing Children):; Evidence of pathologic low trauma or vertebral fracture(s); Have gone through adolescent growth spurt at study entry.
Children with Type-I Diabetes:.