Taking people in United StatesNo phase

Testing Adjusted Limb Lengths in Gastric Bypass Surgery for Severe Obesity

Compares adjusted and standard intestinal limb lengths in adults with severe obesity having gastric bypass.

Key facts

Who runs it: Salvador Navarrete
Where: Cleveland, United StatesSee the site
Trial code: NCT06293703
Registry title: Effect of Limb Length Ratio on Roux-en-Y Gastric Bypass Outcomes (CLIMB II Study)
Status: Recruiting
People taking part: 262 people, planned
Started: 12 Jan 2024
Expected to end: 11 Dec 2030
Type of study: Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested: Surgery
Record updated: 20 March 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with morbid obesity (BMI between 40 and 60) who plan to have Roux-en-Y gastric bypass surgery and agree to long-term follow-up.

Age: 18 Years to 70 Years
Sex: All sexes can join.
Disease stage: Morbid obesity, with a BMI between 40 and 60.
Earlier treatment: People who have had bariatric surgery, or any stomach or small bowel removal, cannot join.

Main reasons for not taking part

Cannot understand or sign a written consent form
Previous bariatric surgery
Previous stomach or small bowel removal
Active cancer
Pregnant, or wanting to become pregnant during the study

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

morbidly obese patients (defined by BMI between 40 and 60)
Patient who understands and accepts the need for a long-term follow-up
Patient who agrees to be included in the study

Who cannot take part

patients with history of previous bariatric surgery procedures
previous gastric or small bowel resection
active cancer
individuals unable to understand and sign a written consent form
presence of a severe and evolutive life threatening pathology unrelated to obesity
pregnancy or desired to be pregnant during the study
mentally unbalanced patients under supervision or guardianship, patient unable to give consent

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 70 years old?

Where in United States

Cleveland ClinicCleveland, United StatesContact: Salvador Navarrete, MDTaking people

About the trial

What the trial wants to find out

The investigators propose a randomized controlled trial comparing BP and roux limb lengths measuring 30 and 15% respectively of patient's total small bowel length versus current standard practice using fixed lengths. The findings would provide further insight into feasibility of standardizing RYGB limb lengths and optimizing resultant weight loss and metabolic effects. The investigators hypothesize RYGB with ratio-adjusted limb lengths (aRYGB) will result in higher total weight loss and resolution of metabolic syndrome comorbidities, including diabetes, hyperlipidemia, and hypertension compared to standard fixed-length RYGB (sRYGB). The study will also utilize the Short Form Rand 36-Item Health Survey (SF36) to determine differences in postoperative quality of life metrics.

The 2 groups in the trial

aRYGBTreatment being tested
BP and roux limb lengths measuring 30% and 15% respectively of patient's total small bowel length.
Treatment: Surgery
sRYGBExisting treatment, for comparison
Standard fixed-length RYGB
Treatment: Surgery