Measures how common sickle cell trait and disease are across Uganda
Studies how often sickle cell trait and disease occur in Ugandans, including babies.
Plain-language title generated from the registry record
Registry title: Uganda Sickle Surveillance Study (US-3)
Key facts
- Where
- Kampala, UgandaSee the 4 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
This study collects blood samples from babies in Uganda to find out how common sickle cell trait and sickle cell disease are, and to map where they occur.
- Age
- Up to 12 Months
- Sex
- All sexes
Main reasons for not taking part
- Repeat samples from the same person during the study period are not included.
Read by machine on 9 November 2026.
Where in Uganda
- Makerere UniversityKampala, UgandaTaking people
- Minister of HealthKampala, UgandaTaking people
- National Coordinator EID ProgramKampala, UgandaTaking people
- Sickle Cell Clinic Department of Pediatrics & Child Health Mulago HospitalKampala, UgandaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Children's Hospital Medical Center, Cincinnati
- Trial code
- NCT06301893
- Record updated
- 16 June 2026
- Original description
It is estimated that over 250,000 babies are born with sickle cell disease (SCD) annually in sub-Saharan Africa, and only 10% - 50% of them survive beyond five years of age. Data describing the magnitude of the sickle cell problem are lacking in most African countries. The available data on prevalence were mainly from older studies and small numbers of hospitalized patients. In Uganda, approximately 25,000 children are born with SCD but 70-80% die before their 5th birthday. Lehmann and Raper found 'sicklaemia' prevalence of 0.8% and 45% in the Sebei and Bambaa ethnic groups, respectively. A recent study found a SCT and SCD prevalence of 3% - 19% and 0% - 3%, respectively but this study addressed only 5 of Uganda's 111 districts and used a small convenience sample of children aged 6 - 60 months. The objective of this study is to determine the prevalence and map out the burden of SCT and SCD in Uganda.Read full original descriptionShow less
Prevalence and Mapping of Sickle Cell Trait and Disease in Uganda
It is estimated that over 250,000 babies are born with sickle cell disease (SCD) annually in sub-Saharan Africa, and only 10% - 50% of them survive beyond five years of age. Data describing the magnitude of the sickle cell problem are lacking in most African countries. The available data on prevalence were mainly from older studies and small numbers of hospitalized patients. In Uganda, approximately 25,000 children are born with SCD but 70-80% die before their 5th birthday. Lehmann and Raper found 'sicklaemia' prevalence of 0.8% and 45% in the Sebei and Bambaa ethnic groups, respectively. A recent study found a SCT and SCD prevalence of 3% - 19% and 0% - 3%, respectively but this study addressed only 5 of Uganda's 111 districts and used a small convenience sample of children aged 6 - 60 months. The objective of this study is to determine the prevalence and map out the burden of SCT and SCD in Uganda.
Inclusion: Up to 1,000,000 samples may be collected during 2015 - 2030 following primary analysis based on surveillance findings.
Exclusion: Repeat samples on the same individuals during the study period will be excluded.