Tests a clinic improvement approach to prevent tuberculosis in rural South Africa
Tests a clinic improvement method to help prevent and treat tuberculosis.
Plain-language title generated from the registry record
Registry title: Systems Analysis and Improvement Approach to Prevent TB
Key facts
- Where
- Addo, Alexandria, Boesmansriviermond, Hankey, Humansdorp, Jeffrey's Bay, Joubertina, Kareedouw, Kenton on Sea, Kirkwood, Patensie, and Port Alfred, South AfricaSee the 16 sites
Where in South Africa
- Addo ClinicAddo, South AfricaNo longer taking part
- Lukhanyiso ClinicAddo, South AfricaNo longer taking part
- Kwa-Nonqubela ClinicAlexandria, South AfricaNo longer taking part
- Marselle ClinicBoesmansriviermond, South AfricaNo longer taking part
- Masakhane ClinicHankey, South AfricaNo longer taking part
- Humansdorp ClinicHumansdorp, South AfricaNo longer taking part
- Pellsrus ClinicJeffrey's Bay, South AfricaNo longer taking part
- Joubertina CHCJoubertina, South AfricaNo longer taking part
- Louterwater ClinicJoubertina, South AfricaNo longer taking part
- Twee Riviere ClinicJoubertina, South AfricaNo longer taking part
- Kareedouw ClinicKareedouw, South AfricaNo longer taking part
- Kenton On Sea ClinicKenton on Sea, South AfricaNo longer taking part
- Kirkwood ClinicKirkwood, South AfricaNo longer taking part
- Moses Mabida ClinicKirkwood, South AfricaNo longer taking part
- Imizamo Yetho ClinicPatensie, South AfricaNo longer taking part
- Nkwenkwezi ClinicPort Alfred, South AfricaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Boston College
- Trial code
- NCT06314386
- Record updated
- 1 October 2026
- Original description
This randomized trial uses the evidence-based Systems Analysis and Improvement Approach (SAIA) adapted for tuberculosis (SAIA-TB) to assess the comprehensive tuberculosis (TB) care cascade across 16 clinics in rural Eastern Cape, South Africa to improve patient outcomes. The aims of this study are to:Read full original descriptionShow less
SAIA-TB: Using the Systems Analysis and Improvement Approach (SAIA) to Prevent TB in Rural South Africa
This randomized trial uses the evidence-based Systems Analysis and Improvement Approach (SAIA) adapted for tuberculosis (SAIA-TB) to assess the comprehensive tuberculosis (TB) care cascade across 16 clinics in rural Eastern Cape, South Africa to improve patient outcomes. The aims of this study are to:
* Evaluate the effectiveness of SAIA-TB use in clinics on TB cascade outcomes for TB patients and with high-risk contacts * Determine the drivers of SAIA-TB implementation success or failure across clinics
The investigators hypothesize that SAIA-TB implementation will lead to a 20% increase in each of: TB screening, TB preventive treatment initiation, and TB disease treatment initiation during the 18-month intervention period.
Aim 1:; Inclusion Criteria for clinics:; Location in the municipalities of Dr. Beyers Naude, Blue Crane Route, Makana, Ndlambe, Sundays River Valley, Kou-Kamma, or Kouga within the Sarah Baartman district, Eastern Cape, South Africa; Within 2 hours' drive to Gqeberha, where the study office is located; Only one clinic per town/area/location to ensure a mix of rural, semi-rural, semi urban; Clinic capacity/Patient volume > 700 total outpatient attendees per month (8,400 patients per year); Staff size of at least 5 employees with a mixture of at least 2 professional nurses, 1 or 2 pharmacist/pharmacy technicians, at least 1 data capturer, a social worker, and multiple community health workers who are clinic-based or part of ward-based outreach teams; Must have an acting Clinic Manager; Exclusion Criteria for clinics:; Clinic managers and/or staff are unwilling to participate; Aim 2:; Inclusion Criteria:; 18 years and older; Frontline clinical and/or managerial staff, district-level TB management; Ability to provide informed consent; Exclusion Criteria:; Under age 18; Unwilling to provide informed consent.