Tuberculosis trials in South Africa

In South Africa 33 Also abroad 197

33 trials · From ClinicalTrials.gov, checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
Rapid Research in Diagnostics Development for TB Network
Where
Cape Town
Age
12 years and over
People
26,436 worldwide
Run by
University of California, San Francisco
See details and how to joinNCT04923958
No phaseNot yet taking people in South Africa
Pulmonary Rehabilitation in African Countries
Where
Johannesburg
Age
18 years and over
People
150 worldwide
Run by
University of Edinburgh
See details and how to joinNCT07602673
Phase 2Taking people
Evaluating the Safety and Immunogenicity of MTBVAC
Where
Cape Town, Chatsworth, Durban, Isipingo, Johannesburg, Klerksdorp, Ladysmith, Rustenburg, Soshanguve, Westdene, Worcester
Age
12 years to 55 years
People
276
Run by
HIV Vaccine Trials Network
See details and how to joinNCT05947890
No phaseTaking people
Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB Treatment
Where
East London, Pietermaritzburg, Port Elizabeth, Port Shepstone
Age
18 years and over
People
2,944
Run by
Johns Hopkins University
See details and how to joinNCT05671718
Phase 3Taking people
Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial)
Where
Johannesburg
Age
16 years and over
People
784 worldwide
Run by
University College, London
See details and how to joinNCT07163143
Phase 3Taking people
A Study of Quabodepistat-containing Regimens for the Treatment of Drug-resistant Pulmonary Tuberculosis
Where
Belville, Cape Town, Durban, East London, Johannesburg, Klerksdorp, Port Elizabeth, Pretoria, Rustenburg, Soweto
Age
14 years and over
People
532 worldwide
Run by
Otsuka Pharmaceutical Development & Commercialization, Inc.
See details and how to joinNCT07209761
No phaseTaking people
Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)
Where
Cape Town
Age
Up to 65 years
People
2,100 worldwide
Run by
University of California, San Francisco
See details and how to joinNCT05989802
Phase 2Taking people
Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB
Where
Cape Town, George
Age
18 years and over
People
2,500 worldwide
Run by
University College, London
See details and how to joinNCT06114628
No phaseEnrolling by invitation
Systems Analysis and Improvement Approach to Prevent TB
Where
Addo, Alexandria, Boesmansriviermond, Hankey, Humansdorp, Jeffrey's Bay, Joubertina, Kareedouw, Kenton on Sea, Kirkwood, Patensie, Port Alfred
Age
0 years and over
People
19,560
Run by
Boston College
See details and how to joinNCT06314386
Phase 2Not yet taking people in South Africa
Study of Combinations of Novel Promising Drugs for Pulmonary Tuberculosis
Where
Cape Town
Age
18 years to 65 years
People
135
Run by
TASK Applied Science
See details and how to joinNCT07773610
No phaseTaking people
South Africa Smoking Cessation and Engagement in HIV/TB Care Care
Where
Rondebosch
Age
18 years and over
People
83
Run by
Massachusetts General Hospital
See details and how to joinNCT05842161
Phase 2Taking people
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial
Where
Klerksdorp
Age
18 years to 45 years
People
40
Run by
North-West University, South Africa
See details and how to joinNCT07118059
Phase 2Taking people
Sorfequiline-based Regimens in Adults With Newly Diagnosed Drug-sensitive Pulmonary TB
Where
Brits, Cape Town, East London, Klerksdorp, Port Elizabeth, Rustenburg, Soshanguve, Wentworth
Age
18 years to 65 years
People
100 worldwide
Run by
Global Alliance for TB Drug Development
See details and how to joinNCT07672405
Phase 2Taking people
Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary Tuberculosis
Where
Bethelsdorp, Brits, Cape Town, Durban, East London, George, Johannesburg, Pretoria, Tembisa
Age
18 years to 65 years
People
150
Run by
Gates Medical Research Institute
See details and how to joinNCT07525427
Phase 3Taking people
Shortened Regimen for Drug-susceptible TB in Children
Where
Durban
Age
0 days to 9 years
People
860 worldwide
Run by
Johns Hopkins University
See details and how to joinNCT06253715
No phaseTaking people
Testing Health Workers At Risk to Advance Our Understanding of TB Infection
Where
Cape Town
Age
18 years to 100 years
People
300
Run by
Beth Israel Deaconess Medical Center
See details and how to joinNCT06221488
Phase 3Not yet taking people in South Africa
A 6-Month MDR-END Plus Regimen for Rifampicin-Resistant Tuberculosis
Where
Cape Town, Klerksdorp
Age
15 years and over
People
294
Run by
Seoul National University Hospital
See details and how to joinNCT07675954
Phase 3Taking people
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis
Where
Cape Town, Port Elizabeth
Age
15 years and over
People
768 worldwide
Run by
ANRS, Emerging Infectious Diseases
See details and how to joinNCT04145258
Phase 2Taking people
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
Where
Durban, Johannesburg
Age
15 years and over
People
330 worldwide
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT05383742
No phaseTaking people
An Adaptive Randomized Controlled Trial
Where
Durban
Age
18 years and over
People
360
Run by
Columbia University
See details and how to joinNCT05633056
Phase 2/3Taking people
Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI
Where
Stellenbosch
People
3,400 worldwide
Run by
Centers for Disease Control and Prevention
See details and how to joinNCT03474029
No phaseTaking people
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
Where
Cape Town
Age
18 years to 60 years
People
150
Run by
University of Stellenbosch
See details and how to joinNCT04700579
No phaseNot yet taking people in South Africa
Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis
Where
Cape Town
Age
18 years and over
People
280
Run by
University of Cape Town
See details and how to joinNCT05007795
No phaseTaking people
Cough Audio Classification as a TB Triage Test
Where
Cape Town
Age
12 years and over
People
1,751 worldwide
Run by
University of Stellenbosch
See details and how to joinNCT05317247
No phaseTaking people
Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant Tuberculosis
Where
East London
Age
18 years and over
People
280
Run by
Albert Einstein College of Medicine
See details and how to joinNCT06590428