Taking people in United StatesPhase 3
Tests pegozafermin against placebo in liver scarring from fatty liver disease
Tests pegozafermin doses versus placebo in adults with MASH and liver scarring.
Plain-language title generated from the registry record
Registry title: A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)
Key facts
- Where
- Akron, Albany, Albuquerque, Amarillo, Athens, Austin, Baltimore, Bellaire, Bellevue, Birmingham, Brandon, Brownsville, Burlington, Canoga Park, Carmel, Chandler, Charleston, Charlotte, Chattanooga, Chesterfield, Chicago, Clermont, Cleveland, Colorado Springs, Columbia, Conway, Cordova, Coronado, Corpus Christi, Covington, Dalton, Dayton, Denton, DeSoto, Durham, East Greenwich, Edinburg, Escondido, Farmers Branch, Fayetteville, Flagstaff, Florham Park, Flowood, Fort Myers, Fort Sam Houston, Fort Worth, Fountain Valley, Freehold, Fresno, Gardena, Garland, Georgetown, Glen Burnie, Glendale, Greenbelt, Hammond, Hermitage, Hialeah Gardens, Homestead, Houma, Houston, Huntington Park, Inglewood, Iowa City, Jacksonville, Jupiter, Katy, La Jolla, Lady Lake, Lake Charles, Lakewood Rch, Lancaster, Las Vegas, Lehigh Acres, Lewisville, Liberty Township, Lima, Little Rock, Littleton, Long Beach, Los Angeles, Louisville, Lubbock, Maitland, Maplewood, Marietta, Marrero, Miami, Montclair, Morehead City, Nashville, New Albany, New Orleans, New Port Richey, New York, North Little Rock, Ocala, Ocoee, Ogden, Orange, Panorama City, Pasadena, Poway, Raleigh, Rialto, Richmond, Roanoke, Rochester, San Antonio, Santa Ana, Sarasota, Seattle, South Bend, Southlake, Springboro, St Louis, Stafford, Stanford, Sugar Land, Sun City, Tacoma, Tomball, Topeka, Tucson, Tyler, Victorville, Waco, Warren Township, West Monroe, Westlake, Wilmington, Winston-Salem, Winter Park, Wyoming, and Ypsilanti, United StatesSee the 135 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06318169, who can take part
Where in United States
- AkronAkron, United StatesTaking people
- AlbanyAlbany, United StatesTaking people
- AlbuquerqueAlbuquerque, United StatesTaking people
- AmarilloAmarillo, United StatesTaking people
- AthensAthens, United StatesTaking people
- AustinAustin, United StatesTaking people
- BaltimoreBaltimore, United StatesTaking people
- BellaireBellaire, United StatesTaking people
- BellevueBellevue, United StatesTaking people
- BirminghamBirmingham, United StatesTaking people
- BrandonBrandon, United StatesTaking people
- BrownsvilleBrownsville, United StatesTaking people
- BurlingtonBurlington, United StatesTaking people
- Canoga ParkCanoga Park, United StatesTaking people
- CarmelCarmel, United StatesTaking people
- ChandlerChandler, United StatesTaking people
- CharlestonCharleston, United StatesTaking people
- CharlotteCharlotte, United StatesTaking people
- ChattanoogaChattanooga, United StatesTaking people
- ChesterfieldChesterfield, United StatesTaking people
- ChicagoChicago, United StatesTaking people
- ClermontClermont, United StatesTaking people
- ClevelandCleveland, United StatesNo longer taking part
- Colorado SpringsColorado Springs, United StatesNo longer taking part
- ColumbiaColumbia, United StatesTaking people
- ConwayConway, United StatesNo longer taking part
- CordovaCordova, United StatesTaking people
- CoronadoCoronado, United StatesTaking people
- Corpus ChristiCorpus Christi, United StatesTaking people
- CovingtonCovington, United StatesTaking people
- DaltonDalton, United StatesTaking people
- DaytonDayton, United StatesTaking people
- DentonDenton, United StatesTaking people
- DeSotoDeSoto, United StatesTaking people
- DurhamDurham, United StatesTaking people
- East GreenwichEast Greenwich, United StatesTaking people
- EdinburgEdinburg, United StatesTaking people
- EscondidoEscondido, United StatesTaking people
- Farmers BranchFarmers Branch, United StatesTaking people
- FayettevilleFayetteville, United StatesTaking people
- FlagstaffFlagstaff, United StatesNo longer taking part
- Florham ParkFlorham Park, United StatesNo longer taking part
- FlowoodFlowood, United StatesTaking people
- Fort MyersFort Myers, United StatesTaking people
- Fort Sam HoustonFort Sam Houston, United StatesNo longer taking part
- Fort WorthFort Worth, United StatesTaking people
- Fountain ValleyFountain Valley, United StatesTaking people
- FreeholdFreehold, United StatesTaking people
- FresnoFresno, United StatesTaking people
- GardenaGardena, United StatesTaking people
- GarlandGarland, United StatesTaking people
- GeorgetownGeorgetown, United StatesTaking people
- Glen BurnieGlen Burnie, United StatesTaking people
- GlendaleGlendale, United StatesTaking people
- GreenbeltGreenbelt, United StatesTaking people
- HammondHammond, United StatesTaking people
- HermitageHermitage, United StatesTaking people
- Hialeah GardensHialeah Gardens, United StatesTaking people
- HomesteadHomestead, United StatesTaking people
- HoumaHouma, United StatesTaking people
- HoustonHouston, United StatesTaking people
- Huntington ParkHuntington Park, United StatesNo longer taking part
- InglewoodInglewood, United StatesNo longer taking part
- Iowa CityIowa City, United StatesTaking people
- JacksonvilleJacksonville, United StatesTaking people
- JupiterJupiter, United StatesTaking people
- KatyKaty, United StatesTaking people
- La JollaLa Jolla, United StatesTaking people
- Lady LakeLady Lake, United StatesTaking people
- Lake CharlesLake Charles, United StatesTaking people
- Lakewood RchLakewood Rch, United StatesTaking people
- LancasterLancaster, United StatesTaking people
- Las VegasLas Vegas, United StatesTaking people
- Lehigh AcresLehigh Acres, United StatesTaking people
- LewisvilleLewisville, United StatesTaking people
- Liberty TownshipLiberty Township, United StatesTaking people
- LimaLima, United StatesTaking people
- Little RockLittle Rock, United StatesTaking people
- LittletonLittleton, United StatesTaking people
- Long BeachLong Beach, United StatesTaking people
- Los AngelesLos Angeles, United StatesNo longer taking part
- LouisvilleLouisville, United StatesTaking people
- LubbockLubbock, United StatesTaking people
- MaitlandMaitland, United StatesTaking people
- MaplewoodMaplewood, United StatesTaking people
- MariettaMarietta, United StatesTaking people
- MarreroMarrero, United StatesTaking people
- MiamiMiami, United StatesTaking people
- MontclairMontclair, United StatesTaking people
- Morehead CityMorehead City, United StatesNo longer taking part
- NashvilleNashville, United StatesTaking people
- New AlbanyNew Albany, United StatesTaking people
- New OrleansNew Orleans, United StatesNo longer taking part
- New Port RicheyNew Port Richey, United StatesTaking people
- New YorkNew York, United StatesTaking people
- North Little RockNorth Little Rock, United StatesTaking people
- OcalaOcala, United StatesTaking people
- OcoeeOcoee, United StatesTaking people
- OgdenOgden, United StatesTaking people
- OrangeOrange, United StatesTaking people
- Panorama CityPanorama City, United StatesNo longer taking part
- PasadenaPasadena, United StatesTaking people
- PowayPoway, United StatesTaking people
- RaleighRaleigh, United StatesTaking people
- RialtoRialto, United StatesTaking people
- RichmondRichmond, United StatesTaking people
- RoanokeRoanoke, United StatesTaking people
- RochesterRochester, United StatesTaking people
- San AntonioSan Antonio, United StatesTaking people
- Santa AnaSanta Ana, United StatesNo longer taking part
- SarasotaSarasota, United StatesTaking people
- SeattleSeattle, United StatesTaking people
- South BendSouth Bend, United StatesTaking people
- SouthlakeSouthlake, United StatesTaking people
- SpringboroSpringboro, United StatesTaking people
- St LouisSt Louis, United StatesTaking people
- StaffordStafford, United StatesTaking people
- StanfordStanford, United StatesTaking people
- Sugar LandSugar Land, United StatesTaking people
- Sun CitySun City, United StatesTaking people
- TacomaTacoma, United StatesTaking people
- TomballTomball, United StatesTaking people
- TopekaTopeka, United StatesTaking people
- TucsonTucson, United StatesTaking people
- TylerTyler, United StatesTaking people
- VictorvilleVictorville, United StatesTaking people
- WacoWaco, United StatesTaking people
- Warren TownshipWarren Township, United StatesTaking people
- West MonroeWest Monroe, United StatesTaking people
- WestlakeWestlake, United StatesTaking people
- WilmingtonWilmington, United StatesTaking people
- Winston-SalemWinston-Salem, United StatesTaking people
- Winter ParkWinter Park, United StatesTaking people
- WyomingWyoming, United StatesTaking people
- YpsilantiYpsilanti, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hoffmann-La Roche
- Trial code
- NCT06318169EU 2023-509912-27-00
- Record updated
- 23 October 2026
- Original description
The study will assess the efficacy and safety of 2 dose regimens of pegozafermin compared to placebo for the treatment of liver fibrosis stage F2 or F3 in adult participants with MASH.Read full original descriptionShow less
A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Metabolic Dysfunction-Associated Steatohepatitis (MASH) and Fibrosis
The study will assess the efficacy and safety of 2 dose regimens of pegozafermin compared to placebo for the treatment of liver fibrosis stage F2 or F3 in adult participants with MASH.
Inclusion: Males or non-pregnant females aged between 18 and 80 years (inclusive) at time of signing the informed consent form (ICF); Biopsy-confirmed MASH with fibrosis stage F2 or F3; Body mass index (BMI) at screening ≥25.0 kilograms (kg)/meters squared (m\^2) (≥23 kg/m\^2 for Asian participants).
Exclusion: Participants taking vitamin E (>400 international units [IU]/day) or pioglitazone must be on stable dose for at least 6 months prior to Screening; Other inclusion and exclusion criteria may apply; Chronic liver diseases other than MASH; Have type 1 diabetes or poorly controlled type 2 diabetes; Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) ≥250 units per liter (U/L); Evidence of cirrhosis on screening liver biopsy.