Studying amyotrophic lateral sclerosis through biomarkers to understand its variability
Studies how biomarkers help group adults with amyotrophic lateral sclerosis by their symptoms.
Plain-language title generated from the registry record
Registry title: Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
Key facts
- Where
- Milan and Torino, ItalySee the 3 sites
Where in Italy
- Ospedale San LucaMilan, ItalyTaking people
- Ospedale San RaffaeleMilan, ItalyTaking people
- AOU Città della Salute e della ScienzaTorino, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Istituto Auxologico Italiano
- Trial code
- NCT06318598
- Record updated
- 7 May 2025
- Original description
The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are:Read full original descriptionShow less
Dissezione Fenotipica Guidata da Biomarcatori Della Sclerosi Laterale Amiotrofica/Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are:
* Which set of biomarkers explain genotypic-phenotypic correlations in ALS? * Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups?
Participants will undergo:
* neurological evaluation * neurophysiological evaluation * neuropsychological evaluation * whole exome sequencing * biomarker measurement in CSF and plasma
Inclusion: diagnosis of ALS or other motor neuron disease; residence near the study centers.
Exclusion: refusal to participate to the study; unable/unwilling to perform follow-up visits.