ALS (motor neurone disease) trials in Italy

In Italy 28 Also abroad 225

28 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

No phaseTaking people
High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project
Where
Genova, Milan, Modena, Montescano, Pavia, Roma, Telese Terme
Age
18 years to 80 years
People
60
Run by
Istituti Clinici Scientifici Maugeri SpA
See details and how to joinNCT06881979
Phase 2Not yet taking people in Italy
A RANDOMIZED, PLACEBO-CONTROLLED, MULTICENTER, CLINICAL TRIAL OF COLCHICINE IN AMYOTROPHIC LATERAL SCLEROSIS (CO-ALS II)
Where
Milan, Modena, Naples, Novara, Padova, Pavia
Age
18 years and over
People
87
Run by
Azienda Ospedaliero Universitaria Di Modena
See details and how to join2026-526460-20-00 · EU 2026-526460-20-00
Phase 3Taking people
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
Where
Caserta, Milan, Modena, Padova, Torino
Age
18 years to 80 years
People
500 worldwide
Run by
Prilenia
See details and how to joinNCT07322003
No phaseNot yet taking people in Italy
PhiCube for Bilateral Upper Limb Neuromotor and Cognitive Rehabilitation in Adults
Where
Bari, Milan, Montescano, Telese Terme
Age
18 years to 85 years
People
80
Run by
Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato
See details and how to joinNCT07865260
Phase 2/3Taking people
Trial on the Biological and Clinical Effects of Acetyl-L-carnitine in ALS
Where
Ancona, Bergamo, Bologna, Gussago, Milan, Modena, Naples, Novara, Padova, Palermo, Pavia, Pergine Valsugana (TN), Perugia, Pisa, Rome, San Donato Milanese
Age
18 years and over
People
246 worldwide
Run by
Mario Negri Institute for Pharmacological Research
See details and how to joinNCT06126315 · EU 2023-509853-29-00
Phase 2Not yet taking people in Italy
Colchicine Effect on Amyotrophic Lateral Sclerosis Patients
Where
Milan, Modena, Naples, Novara, Pavia
Age
18 years to 80 years
People
87
Run by
Azienda Ospedaliero-Universitaria di Modena
See details and how to joinNCT07813858
No phaseTaking people
Neurodegenerative Diseases Progression Markers (MARKERS-NDD)
Where
Cassino
Age
10 years and over
People
600
Run by
Casa di Cura San Raffaele Cassino
See details and how to joinNCT06596746
Phase 2Taking people
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
Where
Genoa, Gussago, Milan, Modena, Naples
Age
18 years and over
People
240 worldwide
Run by
Zydus Therapeutics Inc.
See details and how to joinNCT07023835 · EU 2025-522580-15-00
Phase 1/2Taking people
A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis
Where
Milan, Turin
Age
18 years to 75 years
People
56 worldwide
Run by
Leal Therapeutics, Inc
See details and how to joinNCT07660614 · EU 2025-522039-33-00
No phaseNot yet taking people in Italy
Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients
Where
Bari, Costa Masnaga, Milan, Montescano, Pavia, Pisa, Telese Terme
Age
18 years and over
People
70
Run by
Marta Mondellini
See details and how to joinNCT07616050
No phaseTaking people
ALS/MND Natural History Study Data Repository
Where
Milan
Age
18 years to 90 years
People
5,000 worldwide
Run by
Massachusetts General Hospital
See details and how to joinNCT05966038
Phase 3Taking people
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS (PREVAiLS)
Where
Milan, Modena, Naples, Padova, Turin
Age
18 years and over
People
420 worldwide
Run by
Ferrer Internacional S.A.
See details and how to join2025-524002-16-00 · EU 2025-524002-16-00
No phaseEnrolling by invitation
Tracking and Predicting How Brain Damage Spreads in Neurodegenerative Diseases
Where
Milan
Age
20 years to 85 years
People
645
Run by
IRCCS San Raffaele
See details and how to joinNCT07567664
No phaseTaking people
Longitudinal Assessment of Autonomic and Sensory Nervous System in ALS
Where
Naples, Telese Terme
Age
18 years and over
People
100
Run by
Istituti Clinici Scientifici Maugeri SpA
See details and how to joinNCT05747937
No phaseTaking people
Needs of ALS Patients With C9orf72 Mutation and Their Caregivers
Where
Milan, Pavia
Age
18 years and over
People
208
Run by
Istituto Auxologico Italiano
See details and how to joinNCT07302321
No phaseTaking people
LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS
Where
Milan
Age
18 years and over
People
140
Run by
Istituto Auxologico Italiano
See details and how to joinNCT07312240
Phase 2Taking people
Neural Stem Cell Treatment for Amyotrophic Lateral Sclerosis: A multicenter, randomized placebo controlled and biological endpoints clinical Trial
Where
Novara, Padova, Palermo, San Giovanni Rotondo
Age
18 years to 64 years
People
30
Run by
Casa Sollievo Della Sofferenza
See details and how to join2024-518888-35-00 · EU 2024-518888-35-00
No phaseTaking people
Translating Single-cell Vulnerability Into Novel ALS Biomarkers and Therapeutic Targets: Towards a Liquid Nerve Biopsy
Where
Milan, Monserrato, Naples
Age
18 years and over
People
400
Run by
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
See details and how to joinNCT07268833
No phaseTaking people
Omics Sciences for the Identification of Pathogenetic Mechanisms and Biomarkers in Neurodegenerative Diseases
Where
Genoa
Age
18 years and over
People
1,200
Run by
Ospedale Policlinico San Martino
See details and how to joinNCT07235111
Phase 3Taking people
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients
Where
Baggiovara, Brescia, Gussago, Milan, Novara, Padova, Pavia, Torino
Age
18 years to 81 years
People
495 worldwide
Run by
AB Science
See details and how to joinNCT03127267
No phaseTaking people
At-home Treatment With Cortico-spinal tDCS for Amyotrophic Lateral Sclerosis
Where
Trieste
Age
18 years and over
People
40
Run by
University of Trieste
See details and how to joinNCT07006571
No phaseTaking people
Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases
Where
Milan
Age
18 years and over
People
200
Run by
Istituto Auxologico Italiano
See details and how to joinNCT06318585
No phaseTaking people
Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
Where
Milan, Torino
Age
18 years and over
People
200
Run by
Istituto Auxologico Italiano
See details and how to joinNCT06318598
No phaseTaking people
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS
Where
Milan, Naples, Torino
Age
18 years and over
People
200
Run by
A.O.U. Città della Salute e della Scienza
See details and how to joinNCT06917924
No phaseTaking people
Discovery and Validation of Protein Structural Complexes in Circulating Biofluids As Novel Biomarkers for Early Diagnosis, Prognosis and Therapeutic Management of Patients Affected by Neurodegenerative Disorders
Where
Pozzilli
Age
20 years and over
People
110
Run by
Neuromed IRCCS
See details and how to joinNCT06803784