Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Key facts
- Where
- Edmonton, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 18 years old?
Source: NCT06325280, who can take part
Where in Canada
- University of AlbertaEdmonton, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Alberta
- Trial code
- NCT06325280
- Record updated
- 16 March 2026
- Original description
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.Read full original descriptionShow less
Utilizing Exercise Cardiovascular and Skeletal Magnetic Resonance Imaging to Evaluate Factors Associated With Cardiorespiratory Fitness in Children With Acquired and Congenital Heart Disease
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.
Inclusion: 10 - 18 year olds followed at the Stollery Children's Hospital; Heart transplant recipients ≥6 months post-transplant; Have a moderate-complex congenital heart disease diagnosis.
Exclusion: Clinical antibody- or cellular-mediated rejection within 3-months of the assessment or during the study period (for HTRs); Previous involvement in a CR or exercise intervention program; Previous exercise stress test demonstrating sustained arrhythmias, ST segment elevation or depression greater than 3mm, an inappropriate rise in blood pressure (BP) (<20 mmHg) or a systolic BP >200 mmHg, or symptoms of chest pain or syncope; History of chest pain on exertion; unrepaired/unpalliated CHD; Arrhythmias in the last year (including supraventricular tachycardia, ventricular tachycardia, atrioventricular block or history of (Mobitz II or worse)); New York Heart Association class II or worse symptoms; Active medical inter-current illness limiting ability to participate; Cognitive impairment limiting the communication needed for the exercise MRI; Non-English speaking; Exercise restricted by the patient's clinical cardiologist; Resting arterial saturation <85% or oxygen requirements; Moderate ventricular systolic dysfunction (or worse) at the most recent echocardiogram; Research MRI contraindications (e.g. any type of pacemaker), or any orthopedic limitation preventing exercise testing; Extracardiac or congenital abnormality limiting the participant's functional ability to exercise; Pregnant.