Exercise MRI scans to study heart and muscle work in children with heart disease
Uses MRI scans during exercise to study heart and muscle function in children.
Plain-language title generated from the registry record
Registry title: Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Key facts
- Where
- Edmonton, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and teens aged 10 to 18 treated at the Stollery Children's Hospital. They are either heart transplant recipients or have moderate-complex congenital heart disease.
- Age
- 10 to 18 years
- Sex
- All sexes can join.
- Disease stage
- Heart transplant at least 6 months ago, or a moderate-complex congenital heart disease diagnosis.
- Earlier treatment
- Heart transplant recipients must be at least 6 months after the transplant. People who took part in a cardiac rehab or exercise program before cannot join.
Main reasons for not taking part
- Does not speak English
- Exercise restricted by their heart doctor
- Rejection of the transplant within the last 3 months or during the study
- Unrepaired or unpalliated congenital heart disease
- Pregnant
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 18 years old?
Source: NCT06325280, who can take part
Where in Canada
- University of AlbertaEdmonton, CanadaContact: Rae FoshaugTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Alberta
- Trial code
- NCT06325280
- Record updated
- 16 March 2026
- Original description
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.Read full original descriptionShow less
Utilizing Exercise Cardiovascular and Skeletal Magnetic Resonance Imaging to Evaluate Factors Associated With Cardiorespiratory Fitness in Children With Acquired and Congenital Heart Disease
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.
Inclusion: 10 - 18 year olds followed at the Stollery Children's Hospital; Heart transplant recipients ≥6 months post-transplant; Have a moderate-complex congenital heart disease diagnosis.
Exclusion: Clinical antibody- or cellular-mediated rejection within 3-months of the assessment or during the study period (for HTRs); Previous involvement in a CR or exercise intervention program; Previous exercise stress test demonstrating sustained arrhythmias, ST segment elevation or depression greater than 3mm, an inappropriate rise in blood pressure (BP) (<20 mmHg) or a systolic BP >200 mmHg, or symptoms of chest pain or syncope; History of chest pain on exertion; unrepaired/unpalliated CHD; Arrhythmias in the last year (including supraventricular tachycardia, ventricular tachycardia, atrioventricular block or history of (Mobitz II or worse)); New York Heart Association class II or worse symptoms; Active medical inter-current illness limiting ability to participate; Cognitive impairment limiting the communication needed for the exercise MRI; Non-English speaking; Exercise restricted by the patient's clinical cardiologist; Resting arterial saturation <85% or oxygen requirements; Moderate ventricular systolic dysfunction (or worse) at the most recent echocardiogram; Research MRI contraindications (e.g. any type of pacemaker), or any orthopedic limitation preventing exercise testing; Extracardiac or congenital abnormality limiting the participant's functional ability to exercise; Pregnant.