Ultrasound imaging of the mouth to study oral soft tissue lesions
Tests an intraoral ultrasound scan on mouth lesions in adults with oral squamous cell carcinoma.
Plain-language title generated from the registry record
Registry title: "Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON)
Key facts
- Where
- Pisa, ItalySee the site
Where in Italy
- Università di PisaPisa, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Pisa
- Trial code
- NCT06336941
- Record updated
- 25 February 2026
- Original description
Oral diseases are currently diagnosed by means of clinical examination and supported by surgical biopsy procedures. In particular, daily oral medicine practice is lacking the use of a routine diagnostic support to the visualization of anatomical structures located beyond the mucosal surface. Considering the growing interest in minimally invasive diagnosis, the possibility of having an imaging technique dedicated to the investigation of oral soft tissues and their alterations may be instrumental to support the clinical diagnosis. Therefore, attempts to introduce conventional ultrasonography (US) to the diagnostic work-up of pathological conditions of the head and neck have been done, exploiting the unique features of this technique in terms of limited invasive- ness, repeatability, and cost efficiency.Read full original descriptionShow less
Intraoral Ultra-High Frequency Ultrasound of Oral Soft Tissue Lesions
Oral diseases are currently diagnosed by means of clinical examination and supported by surgical biopsy procedures. In particular, daily oral medicine practice is lacking the use of a routine diagnostic support to the visualization of anatomical structures located beyond the mucosal surface. Considering the growing interest in minimally invasive diagnosis, the possibility of having an imaging technique dedicated to the investigation of oral soft tissues and their alterations may be instrumental to support the clinical diagnosis. Therefore, attempts to introduce conventional ultrasonography (US) to the diagnostic work-up of pathological conditions of the head and neck have been done, exploiting the unique features of this technique in terms of limited invasive- ness, repeatability, and cost efficiency.
In the literature, both extraoral and intraoral applications of US have been reported. Extraoral applications mainly focus on the characterization of oral and maxillofacial swellings of various origin, while intraoral applications mostly involve the study of malignant lesions in terms of tumor thickness and depth of invasion. The aim of the present protocol is to evaluate the role of intraoral ultra-high frequency ultrasonography in the study of oral mucosal lesions.
Inclusion: Clinical diagnosis of oral squamous cell carcinoma; Eligibility for surgical treatment; Acceptance to be included in the study.
Exclusion: Uncontrolled chronic diseases and/or conditions hindering the participation in the study; Oral lesions other than oral squamous cell carcinoma; Pregnant or breastfeeding patients; Denial of inclusion in the study.