Head and neck cancer trials in Italy

In Italy 72 Also abroad 942

72 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
LYSARI – LYmphocyte-Sparing And Radio-Immunotherapy in Head and neck carcinoma - A multicenter, randomised 2*2 factorial design comparing standard to reduced-target volume radiotherapy with or without all-trans retinoic acid (ATRA) in patients with lateralised oropharyngeal, laryngeal and hypopharyngeal squamous cell carcinoma.
Where
Florence, Rome, Rozzano, Venice
Age
18 years and over
People
630 worldwide
Run by
Centre Leon Berard
See details and how to join2022-501315-13-00 · EU 2022-501315-13-00
Phase 3Taking people
A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer
Where
Milan, Naples, Palermo, Pavia, Rome, Rozzano
Age
18 years and over
People
600 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07276399 · EU 2025-521917-24-00
Phase 1/2Taking people
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
Where
Milan
Age
18 years and over
People
560 worldwide
Run by
Genmab
See details and how to joinNCT03526835 · EU 2024-513627-16-01
Phase 2/3Taking people
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
Where
Bologna, Cagliari, Florence, Lecce, Milan, Naples, Padova, Palermo, Pavia, Pisa, Rome, Rozzano, Siena
Age
18 years and over
People
650 worldwide
Run by
Bicara Therapeutics
See details and how to joinNCT06788990 · EU 2024-519654-37-00
Phase 2Taking people
DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
Where
Bergamo, Brescia, Ferrara, Florence, Milan, Modena, Pavia, Verona
Age
18 years and over
People
750 worldwide
Run by
DualityBio Inc.
See details and how to joinNCT06953089 · EU 2025-523895-22-00
Phase 2/3Taking people
Ordastobart (INBRX-106) Add-on to Pembrolizumab in 1L HPV+ PD-L1+ R/M OPSCC (HexAgon-HN)
Where
Milan, Naples, Pavia
Age
18 years and over
People
450 worldwide
Run by
Inhibrx Biosciences, Inc
See details and how to joinNCT06295731
Phase 1/2Taking people
A Study to Investigate ALE.P02 as a Monotherapy or in Combination With Pembrolizumab in Adult Patients With Selected CLDN1+ Solid Tumors
Where
Milan, Ravenna, Roma, Verona
Age
18 years and over
People
235 worldwide
Run by
Alentis Therapeutics AG
See details and how to joinNCT06747585 · EU 2024-515459-39-00
Phase 2Taking people
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
Where
Bergamo, Genova, Naples, Verona
Age
18 years and over
People
740 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06172478 · EU 2023-507641-29-00
Phase 1/2Taking people
A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
Where
Candiolo, Milan, Naples, Rome, Rozzano
Age
18 years and over
People
680 worldwide
Run by
Daiichi Sankyo
See details and how to joinNCT06330064 · EU 2023-509632-26-00
Phase 2Taking people
A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Where
Milan, Pieve Emanuele
Age
18 years and over
People
120 worldwide
Run by
Regeneron Pharmaceuticals
See details and how to joinNCT06769698 · EU 2024-517620-19-00
No phaseTaking people
Psychological and Psychiatric prOfile in Glioblastoma and Head and Neck Cancer
Where
Roma
Age
18 years to 75 years
People
207
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT06385132
No phaseTaking people
Health Oriented Protocol for Epidermal Radiodermatitis
Where
Roma
Age
18 years and over
People
80
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07129525
Phase 2Taking people
A Study Evaluating Ficerafusp Alfa (BCA101) QW in Combination With Pembrolizumab vs Alternative Ficerafusp Alfa Dosing in 1L R or M HNSCC
Where
Meldola, Milan, Naples
Age
18 years and over
People
160 worldwide
Run by
Bicara Therapeutics
See details and how to joinNCT07807163 · EU 2026-526741-10-00
Phase 3Taking people
A Study to Evaluate CRB-701 Compared to Investigator's Choice Therapy in Previously Treated Oropharyngeal Squamous Cell Carcinoma
Where
Ancona, Milan, Modena, Pisa, Prato, Rozzano, Verona
Age
18 years and over
People
260 worldwide
Run by
Corbus Pharmaceuticals Inc.
See details and how to joinNCT07768189 · EU 2026-527123-94-00
Phase 1/2Taking people
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
Where
Candiolo, Milan, Naples, Rome, Rozzano
Age
12 years and over
People
300 worldwide
Run by
PMV Pharmaceuticals, Inc
See details and how to joinNCT04585750
Phase 1Taking people
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
Where
Ancona, Bologna, Florence, Milan, Naples, Ravenna
Age
18 years and over
People
1,394 worldwide
Run by
Exelixis
See details and how to joinNCT05176483 · EU 2023-510061-10-00
Phase 3Taking people
A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
Where
Aviano, Florence, Milan, Modena, Naples, Padova, Pavia, Rozzano
Age
18 years to 130 years
People
1,145 worldwide
Run by
AstraZeneca
See details and how to joinNCT06129864
No phaseNot yet taking people in Italy
A Master Regulator of Lipid-Associated Macrophage Function in Cancer
Where
Roma
Age
18 years and over
People
120
Run by
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
See details and how to joinNCT07848061
Phase 1Taking people
Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
Where
Candiolo, Rozzano
Age
18 years and over
People
540 worldwide
Run by
SystImmune Inc.
See details and how to joinNCT05983432
No phaseTaking people
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
Where
Meldola, Reggio Emilia, Roma
Age
18 years and over
People
2,285 worldwide
Run by
Guardant Health, Inc.
See details and how to joinNCT05059444
Phase 2Taking people
Study of Volrustomig as Monotherapy or in Combination With Anti- Cancer Agents in Participants With Advanced/Metastatic Solid Tumors
Where
Alexandria, Bergamo, Orbassano
Age
18 years to 64 years
People
257 worldwide
Run by
AstraZeneca
See details and how to joinNCT06535607 · EU 2025-523947-36-00
Phase 1/2Taking people
A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
Where
Candiolo, Milan, Naples, Roma, Rozzano, Siena
Age
18 years and over
People
1,109 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT04895709
Phase 1Taking people
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Where
Bologna, Milan, Verona
Age
18 years and over
People
714 worldwide
Run by
Seagen, a wholly owned subsidiary of Pfizer
See details and how to joinNCT05208762 · EU 2023-506604-18-00
No phaseTaking people
Brief Clinical Psychological Intervention With Biofeedback in Head and Neck Cancer
Where
Turin
Age
18 years and over
People
58
Run by
University of Turin, Italy
See details and how to joinNCT07712120
No phaseNot yet taking people in Italy
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
Where
Milan, Pavia
Age
18 years and over
People
38
Run by
University of Pavia
See details and how to joinNCT07692360