Studies cortisol and testosterone levels in men with severe obesity
Looks at hormone levels in men with severe obesity and their link to complications.
Plain-language title generated from the registry record
Registry title: Study of the Steroid Hormone Milieu in Obese Patients
Key facts
- Where
- Oggebbio, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06341699, who can take part
Where in Italy
- Istituto Auxlogico Italiano, Hospital San Giuseppe, PiancavalloOggebbio, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Istituto Auxologico Italiano
- Trial code
- NCT06341699
- Record updated
- 13 May 2025
- Original description
The aim of this observational study is to evaluate the actual secretion of cortisol and testosterone in obese male subjects, together with the receptor sensitivity to these hormones in order to understand whether the hormonal milieu deriving from these parameters is associated with alterations in bone metabolism, lipoprotein concentration and function, and/or the severity and complications of obesity.Read full original descriptionShow less
Studio Del Milieu Steroideo in Pazienti Obesi
The aim of this observational study is to evaluate the actual secretion of cortisol and testosterone in obese male subjects, together with the receptor sensitivity to these hormones in order to understand whether the hormonal milieu deriving from these parameters is associated with alterations in bone metabolism, lipoprotein concentration and function, and/or the severity and complications of obesity.
It will be also investigated if this hormonal milieu is a predictive factor for cardiovascular disease in obese patients.
Eligible subjects are male patients (age 18-80 years) with severe obesity and no other known causes of hypercortisolism or hypogonadism.
Questionnaires for the evaluation of mood and symptoms will be collected upon enrollment, patient's anamnestic and clinical data relating to disease complications, BMI, previous blood tests, cortisol suppression with dexamethasone 1 mg will be collected, and blood sample will be sent to and analyzed at a centralized laboratory for the study of Steroid hormones, bone metabolism, lipoprotein function, genetics and receptor analysis.
Inclusion: morbid obesity.
Exclusion: use of corticosteroids at the time of enrollment; patients suffering from severe systemic pathologies, fever, chronic inflammatory states known to cause PCR >10 mg/dL; the patient's poor understanding of spoken and written Italian; patients suffering from primary pathologies of the testicle, known at enrollment; patients suffering from hypothalamic-pituitary or adrenal pathologies already known at the time of enrollment.