Blood Test to Detect Early-Onset Colorectal Cancer
Tests a non-invasive blood test to detect colorectal cancer in adults under 50.
Plain-language title generated from the registry record
Registry title: Early Onset Colorectal Cancer Detection
Key facts
- Where
- Kawasaki, Mie, Tokyo, and Yamagata, JapanSee the 5 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT06342401, who can take part
Where in Japan
- Kawasaki UniversityKawasaki, JapanTaking people
- Mie UniversityMie, JapanTaking people
- National Cancer Center HospitalTokyo, JapanTaking people
- Tokyo Medical and Dental UniversityTokyo, JapanTaking people
- Yamagata UniversityYamagata, JapanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- City of Hope Medical Center
- Trial code
- NCT06342401
- Record updated
- 7 July 2026
- Original description
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women.Read full original descriptionShow less
Development and Validation fo an Exosome-Based and Machine Learning Powered Liquid Biopsy for the Detection of Early-Onset Colorectal Cancer
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults. Once rare, early-onset colorectal cancer (EOCRC, that is, a CRC diagnosed before the age of 50) now constitutes 10-15% of all newly diagnosed CRC cases and it stands as the first cause of cancer-related death in young men and the second for young women.
This study aims to detect EOCRC with a non-invasive test, using a blood-based molecular assay based on microRNA (ribonucleic acid)
Inclusion: Stage I, II, III, IV colorectal cancer (TNM classification, 8th edition) diagnosed before the age of 50 (EOCRC cases); Received standard diagnostic and staging procedures as per local guidelines, and at least one sample was drawn before receiving any curative-intent treatment; Colonoscopy-proven cancer-free status at the time of study inclusion (Non-disease controls).
Exclusion: Hereditary colorectal cancer syndromes (identified through genetic testing); Inflammatory bowel diseases; Lack of written informed consent.