Testing personalized plant-based diets for heart and metabolic health in adults
Tests personalized plant-based diets rich in polyphenols in adults with obesity.
Plain-language title generated from the registry record
Registry title: Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols
Key facts
- Where
- Parma, ItalySee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT06347094, who can take part
Where in Italy
- Azienda Ospedaliero Universitaria di ParmaParma, ItalyTaking people
- University of Parma - Plesso Biotecnologico IntegratoParma, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Parma
- Trial code
- NCT06347094
- Record updated
- 9 November 2026
- Original description
This chronic study aims at assessing whether the effects of a personalized, plant-based diet rich in (poly)phenols on cardiometabolic health depend on the capability to metabolize dietary (poly)phenols, creating predictive models able to explain, at individual level, the cardiometabolic response. This study presents an observational part, for targeted recruitment and volunteers characterization, and an experimental part for the dietary and deep phenotyping.Read full original descriptionShow less
Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols (PRE-CARE-DIET)
This chronic study aims at assessing whether the effects of a personalized, plant-based diet rich in (poly)phenols on cardiometabolic health depend on the capability to metabolize dietary (poly)phenols, creating predictive models able to explain, at individual level, the cardiometabolic response. This study presents an observational part, for targeted recruitment and volunteers characterization, and an experimental part for the dietary and deep phenotyping.
Inclusion: Adults (40-80 y.o.); Non-clinically diagnosed for cardiometabolic diseases at baseline examination; At least one of the following risk factors: overweight or obese, central obesity (waist:hip ratio > 0.90 in males and > 0.85 in females or waist circumference ≥ 94 cm in males and ≥ 80 cm in females), hypertension (systolic BP > 130 or diastolic BP > 85 mm Hg), low high-density lipoprotein cholesterol levels (< 40 mg/dL (1.03 mmol/L) in males, < 50 mg/dL (1.29 mmol/L) in females), or elevated total cholesterol (≥ 200 mg/dL), low-density lipoprotein cholesterol (≥ 130 mg/dL (4.1 mmol/L)), triglyceride (> 150 mg/dL (1.7 mmol/L)), fasting glucose (> 100 mg/dL (5.6 mmol/L)) levels, or microalbuminuria (urinary albumin excretion ratio ≥ 20 μg/min or albumin:creatinine ratio ≥ 30 mg/g). In addition, it is necessary that the weight has been stable for at least 3 months. Similarly, concerning an ongoing therapy with medication or supplements, these must have been in use for at least 3 months.
Exclusion: Hormone therapy (other than that used for hypothyroidism, birth-control or menopause symptoms); Antibiotic therapy within the last month before the study; Past cardiovascular events and metabolic diseases including diabetes; Inflammatory bowel diseases or gastro-intestinal surgery (other than appendectomy); Renal or hepatic diseases; Immunodeficiency or autoimmune diseases (other than well-compensated hypothyroidism); Mental disorders; Food allergies associated with the consumption of plant foods or foods that will be provided in the study; Presence of chewing or swallowing disorders; Levels of estimated Glomerular Filtration (eGFR) < 60 mL/min/1.73 m²; Aspartate transaminase (AST)/alanine aminotransferase (ALT) 2.5 times the upper limits of normal; BMI < 18.5 or > 40.0 kg/m²; Cholecystectomy within the past 5 years; Difficulties or major inconveniences in changing dietary habits or adhering to a plant-based Mediterranean-type diet; Pregnancy or lactation.