Computer Alerts to Help Prevent Stroke in People With Atrial Fibrillation
Tests computer alerts that help doctors prevent stroke in adults with atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Computerized Decision Support to Prevent Stroke in Atrial Fibrillation
Key facts
- Where
- Boston and Edgewood, United StatesSee the 2 sites
Where in United States
- Mass General BrighamBoston, United StatesNo longer taking part
- St. Elizabeth HealthEdgewood, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Brigham and Women's Hospital
- Trial code
- NCT06355986
- Record updated
- 25 February 2026
- Original description
Atrial fibrillation (AF) is the most preventable cause of stroke. However, despite widely available risk stratification tools, numerous options for oral anticoagulation, and evidence-based practice guidelines, anticoagulation for stroke prevention in AF is consistently under-prescribed. In a pair of observational cohort analyses within the Mass General Brigham (MGB) health system, prescription of anticoagulation for stroke prevention in AF was less frequent in ambulatory clinic patients than in those who were hospitalized at the time of assessment (46.9% vs. 57.2%). Two single academic medical center randomized controlled trials demonstrated success for increasing adherence to guideline recommendations for stroke prevention in AF. To address the feasibility and impact of a computerized decision support (CDS) strategy in the non-tertiary care, community medical center setting, this study will involve a multicenter, cluster-randomized controlled trial of a more sophisticated CDS focused not only on implementation stroke prevention but also on bleeding risk assessment and management.Read full original descriptionShow less
Community-Based, Cluster-Randomized Trial of Electronic Alert-Based Computerized Decision Support to Prevent Stroke in High-Risk Ambulatory Patients With Atrial Fibrillation (AF-ALERT3)
Atrial fibrillation (AF) is the most preventable cause of stroke. However, despite widely available risk stratification tools, numerous options for oral anticoagulation, and evidence-based practice guidelines, anticoagulation for stroke prevention in AF is consistently under-prescribed. In a pair of observational cohort analyses within the Mass General Brigham (MGB) health system, prescription of anticoagulation for stroke prevention in AF was less frequent in ambulatory clinic patients than in those who were hospitalized at the time of assessment (46.9% vs. 57.2%). Two single academic medical center randomized controlled trials demonstrated success for increasing adherence to guideline recommendations for stroke prevention in AF. To address the feasibility and impact of a computerized decision support (CDS) strategy in the non-tertiary care, community medical center setting, this study will involve a multicenter, cluster-randomized controlled trial of a more sophisticated CDS focused not only on implementation stroke prevention but also on bleeding risk assessment and management.
Inclusion: Male and Female; Age ≥ 18 years; Problem list entry of atrial fibrillation or atrial flutter; CHA2DS2VASc score ≥ 2 for males; CHA2DS2VASc score ≥ 3 for females; No prescription for anticoagulant therapy.
Exclusion: Active prescription for anticoagulant therapy; CHA2DS2VASc score < 2 for males; CHA2DS2VASc score ≤ 2 for females.