Testing Two Magnesium Doses for Fast, Irregular Heartbeat
Tests magnesium at 2g and 4g against saline in adults with atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
Key facts
- Where
- Oak Lawn, United StatesSee the site
- Phase
- Phase 3
Where in United States
- Advocate Christ Medical Center Emergency Department (ACMC ED)Oak Lawn, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wake Forest University Health Sciences
- Trial code
- NCT06376916
- Record updated
- 28 September 2026
- Original description
The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.Read full original descriptionShow less
Atrial Tachycardia Reduction With Intravenous Use of Magnesium (ATRIUM) Study: Comparing Magnesium 2g Versus 4g Versus Placebo in the Incidence of Treating AFF RVR
The purpose of this prospective, randomized, double-blinded study is to further evaluate the safety and efficacy of varying doses of intravenous magnesium in the treatment of AFF RVR.
Inclusion: Age > 18 years or older; Able to provide informed consent; Primary diagnosis AFF RVR greater than or equal to 120 bpm; Diltiazem as rate control agent; English speaking.
Exclusion: Previously enrolled in this trial during a different patient encounter; End stage renal disease on hemodialysis or peritoneal dialysis; Acute heart failure exacerbation based on clinical diagnosis, physician exam, bedside echo, and/or additional imaging; Rhythms other than AF, such as sick sinus syndrome or wide-complex ventricular response; Acute myocardial infarction; Allergy or sensitivity to any study drugs; Contraindications to magnesium sulfate (including myasthenia gravis); Hemodynamically unstable patients (SBP <90, MAP <65); Impaired consciousness; Patient in AFF RVR that is highly suspected to be a compensatory mechanism for an alternative clinical diagnosis; Pregnancy defined as a positive urine HCG (human chorionic gonadotropin); Withdrew from study.