Tests an air cleaner for people with COPD at home
Tests whether a home air cleaner helps adults 40 or older with COPD.
Plain-language title generated from the registry record
Registry title: Multi-Center Clean Air Randomized Controlled Trial in COPD
Key facts
- Where
- Ann Arbor, Baltimore, Birmingham, Boston, Cleveland, Iowa City, Lebanon, Los Angeles, Salisbury, and West Reading, United StatesSee the 11 sites
- Phase
- Phase 3
Where in United States
- University of MichiganAnn Arbor, United StatesTaking people
- Johns HopkinsBaltimore, United StatesTaking people
- University of MarylandBaltimore, United StatesTaking people
- University of Alabama, Lung Health CenterBirmingham, United StatesTaking people
- Beth Israel Deaconess Medical CenterBoston, United StatesTaking people
- Cleveland ClinicCleveland, United StatesTaking people
- University of IowaIowa City, United StatesTaking people
- Dartmouth HitchcockLebanon, United StatesTaking people
- University of California, Los AngelesLos Angeles, United StatesTaking people
- Tidal HealthSalisbury, United StatesTaking people
- Reading HospitalWest Reading, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- JHSPH Center for Clinical Trials
- Trial code
- NCT06376994
- Record updated
- 31 July 2026
- Original description
This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk and improving quality of life, functional status, rescue medication use.Read full original descriptionShow less
Multi-Center Clean Air Randomized Controlled Trial in COPD
This is a multi-center randomized, sham-controlled clinical trial to determine the effectiveness of an air cleaner intervention aimed at improving indoor air quality on reducing COPD exacerbation risk and improving quality of life, functional status, rescue medication use.
Inclusion: To be eligible, subjects must meet all these criteria:; Age ≥ 40 years; Self-report of physician diagnosis of COPD; Spirometry confirmed airway obstruction (post-bronchodilator spirometry of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) < 0.7) as defined by the Global Initiative for Obstructive Lung Disease (GOLD) criteria (6, 11); Tobacco exposure ≥ 10 pack-years. This refers to regular cigarette tobacco consumption; Self-reported former smoker of at least 6 months' duration. This does not include e-cigarette use; COPD Assessment Test (CAT) score ≥ 10, Modified Medical Research Council dyspnea scale (mMRC) ≥ 2, or history of moderate or severe exacerbation in the past 12 months (as defined by history of receiving a course of systemic corticosteroids or antibiotics for respiratory problems; or visiting an emergency department or being hospitalized for a COPD exacerbation within the past 12 months.).
Exclusion: Other chronic lung diseases, except asthma; Condition with less than a year of life expectancy (e.g., metastatic cancer) or in hospice; To be eligible, subjects must not meet any one of these criteria:; Living in a location other than home (e.g., long-term care facility, nursing home); Spends >2 months per year in location other than home; or plans to change residence in the next 12 months; Pregnant or breastfeeding; Current air cleaner use in the home (*If the individual is willing to discontinue use of the personal air cleaner, this person can be eligible if all other eligibility has been met); Inability to bring air cleaners (about 15 pounds each) into home, either by self, friend, or relative; Deemed by the study investigator to be unable to complete study protocol, including likely lack of internet connectivity; Participating in another interventional clinical trial.