Checking blood and urine markers against kidney decline in pulmonary hypertension
Looks at blood and urine markers linked to kidney changes in adults with pulmonary hypertension.
Plain-language title generated from the registry record
Registry title: Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension
Key facts
- Where
- Bad Nauheim and Giessen, GermanySee the 2 sites
Where in Germany
- Kerckhoff Klinik Heart and Thorax CenterBad Nauheim, GermanyTaking people
- University Hospital Giessen and Marburg, Campus Giessen, Department of Internal Medicine IIGiessen, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Giessen
- Trial code
- NCT06409624
- Record updated
- 8 September 2026
- Original description
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).Read full original descriptionShow less
Association Between Biomarkers and Kidney Function Decline in Patients With Pulmonary Hypertension
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).
Inclusion: Inpatients aged ≥18 years; Undergoing right heart catheterization (RHC).
Exclusion: if they had received non-steroidal anti-inflammatory drugs or intravenous contrast within 72 hours before RHC; solid organ transplantation; likelihood of receiving advanced therapy (mechanical circulatory assist device/lung or cardiac transplant); active tumor disease requiring targeted therapy; inflammatory or autoimmune disease with renal involvement requiring systemic immunosuppressive treatment; non-kidney failure requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload; polycystic kidney disease; unexplained kidney function decline, defined as serum creatinine increase ≥0.5 mg/dL from baseline within the prior 7 days before RHC; Chronic kidney disease with eGFR <20 ml/min/1.73 m2; multifactorial or indeterminate PH, for which no single underlying mechanism could be reliably classified; prediagnosed glomerulonephritis; postrenal obstruction; single kidney (functional or anatomical); anticipated life expectancy of <12 months; pregnancy or possibility of pregnancy in the next 12 months; inability to cooperate with respiratory maneuvers during renal Doppler; refusal to participate; not available for follow-up visits.