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Taking people in United StatesPhase 3

Tests pegozafermin in adults with liver scarring from fatty liver disease

Tests pegozafermin against placebo in adults with compensated cirrhosis from MASH.

Plain-language title generated from the registry record
Registry title: A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

Key facts

Where
Akron, Albany, Albuquerque, Amarillo, Ann Arbor, Asheville, Athens, Atlanta, Austin, Baltimore, Bellevue, Birmingham, Brownsville, Burlington, Camarillo, Canoga Park, Chandler, Charleston, Charlotte, Chicago, Cincinnati, Clermont, Cleveland, Clinton Township, Columbia, Columbus, Cordova, Coronado, Dayton, DeSoto, Detroit, Durham, East Greenwich, Edinburg, Farmers Branch, Fayetteville, Flagstaff, Florham Park, Flowood, Fort Myers, Fort Worth, Fountain Valley, Framingham, Fresno, Gainesville, Georgetown, Glen Burnie, Glenview, Greenbelt, Greenville, Hammond, Harlingen, Hermitage, Hialeah Gardens, Homestead, Homewood, Houston, Huntington Park, Iowa City, Jacksonville, Kansas City, La Jolla, Lady Lake, Lafayette, Lake Charles, Lakewood Rch, Las Vegas, Lehigh Acres, Lewisville, Liberty Township, Little Rock, Littleton, Los Angeles, Louisville, Lubbock, Maitland, Mansfield, Marietta, Miami, Minneapolis, Nashville, New Albany, New Port Richey, New York, North Little Rock, Ocala, Ocoee, Orlando, Pasadena, Pearland, Peoria, Philadelphia, Phoenix, Pittsburgh, Poway, Rapid City, Redwood City, Rialto, Richmond, Rochester, Sacramento, San Antonio, San Marcos, Sandy City, Santa Ana, Seattle, Somers Point, South Bend, Southlake, St Louis, Sun City, Tacoma, Topeka, Tucson, Tupelo, Tyler, University Park, Viera, Waco, West Jordan, West Monroe, Westlake, Winston-Salem, Winter Park, Wyoming, and Ypsilanti, United StatesSee the 126 sites
Phase
Phase 3

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 75 years old?

Source: NCT06419374, who can take part

Where in United States

  • AkronAkron, United StatesTaking people
  • AlbanyAlbany, United StatesTaking people
  • AlbuquerqueAlbuquerque, United StatesTaking people
  • AmarilloAmarillo, United StatesTaking people
  • Ann ArborAnn Arbor, United StatesTaking people
  • AshevilleAsheville, United StatesTaking people
  • AthensAthens, United StatesTaking people
  • AtlantaAtlanta, United StatesTaking people
  • AustinAustin, United StatesTaking people
  • BaltimoreBaltimore, United StatesTaking people
  • BellevueBellevue, United StatesTaking people
  • BirminghamBirmingham, United StatesTaking people
  • BrownsvilleBrownsville, United StatesTaking people
  • BurlingtonBurlington, United StatesTaking people
  • CamarilloCamarillo, United StatesTaking people
  • Canoga ParkCanoga Park, United StatesTaking people
  • ChandlerChandler, United StatesTaking people
  • CharlestonCharleston, United StatesTaking people
  • CharlotteCharlotte, United StatesTaking people
  • ChicagoChicago, United StatesTaking people
  • CincinnatiCincinnati, United StatesTaking people
  • ClermontClermont, United StatesTaking people
  • ClevelandCleveland, United StatesTaking people
  • Clinton TownshipClinton Township, United StatesTaking people
  • ColumbiaColumbia, United StatesTaking people
  • ColumbusColumbus, United StatesTaking people
  • CordovaCordova, United StatesTaking people
  • CoronadoCoronado, United StatesTaking people
  • DaytonDayton, United StatesTaking people
  • DeSotoDeSoto, United StatesTaking people
  • DetroitDetroit, United StatesTaking people
  • DurhamDurham, United StatesTaking people
  • East GreenwichEast Greenwich, United StatesTaking people
  • EdinburgEdinburg, United StatesNo longer taking part
  • Farmers BranchFarmers Branch, United StatesTaking people
  • FayettevilleFayetteville, United StatesTaking people
  • FlagstaffFlagstaff, United StatesNo longer taking part
  • Florham ParkFlorham Park, United StatesNo longer taking part
  • FlowoodFlowood, United StatesTaking people
  • Fort MyersFort Myers, United StatesTaking people
  • Fort WorthFort Worth, United StatesNo longer taking part
  • Fountain ValleyFountain Valley, United StatesTaking people
  • FraminghamFramingham, United StatesTaking people
  • FresnoFresno, United StatesTaking people
  • GainesvilleGainesville, United StatesTaking people
  • GeorgetownGeorgetown, United StatesTaking people
  • Glen BurnieGlen Burnie, United StatesTaking people
  • GlenviewGlenview, United StatesTaking people
  • GreenbeltGreenbelt, United StatesTaking people
  • GreenvilleGreenville, United StatesNo longer taking part
  • HammondHammond, United StatesTaking people
  • HarlingenHarlingen, United StatesNo longer taking part
  • HermitageHermitage, United StatesTaking people
  • Hialeah GardensHialeah Gardens, United StatesTaking people
  • HomesteadHomestead, United StatesTaking people
  • HomewoodHomewood, United StatesTaking people
  • HoustonHouston, United StatesTaking people
  • Huntington ParkHuntington Park, United StatesNo longer taking part
  • Iowa CityIowa City, United StatesTaking people
  • JacksonvilleJacksonville, United StatesTaking people
  • Kansas CityKansas City, United StatesTaking people
  • La JollaLa Jolla, United StatesTaking people
  • Lady LakeLady Lake, United StatesNo longer taking part
  • LafayetteLafayette, United StatesTaking people
  • Lake CharlesLake Charles, United StatesTaking people
  • Lakewood RchLakewood Rch, United StatesTaking people
  • Las VegasLas Vegas, United StatesTaking people
  • Lehigh AcresLehigh Acres, United StatesTaking people
  • LewisvilleLewisville, United StatesTaking people
  • Liberty TownshipLiberty Township, United StatesTaking people
  • Little RockLittle Rock, United StatesTaking people
  • LittletonLittleton, United StatesTaking people
  • Los AngelesLos Angeles, United StatesTaking people
  • LouisvilleLouisville, United StatesTaking people
  • LubbockLubbock, United StatesNo longer taking part
  • MaitlandMaitland, United StatesNo longer taking part
  • MansfieldMansfield, United StatesTaking people
  • MariettaMarietta, United StatesTaking people
  • MiamiMiami, United StatesTaking people
  • MinneapolisMinneapolis, United StatesTaking people
  • NashvilleNashville, United StatesTaking people
  • New AlbanyNew Albany, United StatesTaking people
  • New Port RicheyNew Port Richey, United StatesTaking people
  • New YorkNew York, United StatesTaking people
  • North Little RockNorth Little Rock, United StatesTaking people
  • OcalaOcala, United StatesTaking people
  • OcoeeOcoee, United StatesTaking people
  • OrlandoOrlando, United StatesNo longer taking part
  • PasadenaPasadena, United StatesTaking people
  • PearlandPearland, United StatesNo longer taking part
  • PeoriaPeoria, United StatesTaking people
  • PhiladelphiaPhiladelphia, United StatesTaking people
  • PhoenixPhoenix, United StatesTaking people
  • PittsburghPittsburgh, United StatesTaking people
  • PowayPoway, United StatesTaking people
  • Rapid CityRapid City, United StatesTaking people
  • Redwood CityRedwood City, United StatesTaking people
  • RialtoRialto, United StatesTaking people
  • RichmondRichmond, United StatesTaking people
  • RochesterRochester, United StatesTaking people
  • SacramentoSacramento, United StatesTaking people
  • San AntonioSan Antonio, United StatesTaking people
  • San MarcosSan Marcos, United StatesTaking people
  • Sandy CitySandy City, United StatesTaking people
  • Santa AnaSanta Ana, United StatesNo longer taking part
  • SeattleSeattle, United StatesTaking people
  • Somers PointSomers Point, United StatesTaking people
  • South BendSouth Bend, United StatesTaking people
  • SouthlakeSouthlake, United StatesTaking people
  • St LouisSt Louis, United StatesTaking people
  • Sun CitySun City, United StatesTaking people
  • TacomaTacoma, United StatesTaking people
  • TopekaTopeka, United StatesTaking people
  • TucsonTucson, United StatesTaking people
  • TupeloTupelo, United StatesNo longer taking part
  • TylerTyler, United StatesTaking people
  • University ParkUniversity Park, United StatesTaking people
  • VieraViera, United StatesTaking people
  • WacoWaco, United StatesTaking people
  • West JordanWest Jordan, United StatesTaking people
  • West MonroeWest Monroe, United StatesTaking people
  • WestlakeWestlake, United StatesTaking people
  • Winston-SalemWinston-Salem, United StatesTaking people
  • Winter ParkWinter Park, United StatesTaking people
  • WyomingWyoming, United StatesTaking people
  • YpsilantiYpsilanti, United StatesTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
Hoffmann-La Roche
Trial code
NCT06419374EU 2023-510395-31-00
Record updated
23 October 2026
Original description
The study will assess the efficacy and safety of pegozafermin administered in participants with biopsy-confirmed and clinically confirmed compensated cirrhosis due to MASH .Read full original descriptionShow less

A Phase 3 Study to Evaluate the Efficacy and Safety of Pegozafermin in Subjects With Compensated Cirrhosis Due to Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ENLIGHTEN-Cirrhosis)

The study will assess the efficacy and safety of pegozafermin administered in participants with biopsy-confirmed and clinically confirmed compensated cirrhosis due to MASH .

Inclusion: Males or non-pregnant females aged between 18 and 75 years (inclusive) at time of signing the informed consent form (ICF); Participants must have type 2 diabetes mellitus diagnosed at least 3 months before screening or at least 2 metabolic risk factors; Evidence of both cirrhosis and MASH etiology, either through a historical biopsy or a biopsy at Screening; Clinical diagnosis of cirrhosis based on the NIT algorithm.

Exclusion: Participants taking vitamin E (>400 international units [IU]/day) must be on stable dose for at least 6 months prior to screening; Other protocol-defined inclusion and exclusion criteria may apply; Liver disorder other than MASH; Have type 1 diabetes mellitus or poorly controlled type 2 diabetes mellitus; ALT or aspartate aminotransferase (AST) ≥250 units per liter (U/L); History or evidence of hepatic decompensation; History or evidence of hepatocellular carcinoma.

ClinicalTrials.gov NCT06419374 · EU CTIS 2023-510395-31-00