Tests deep brain stimulation for treatment-resistant depression in adults
Tests brain stimulation as added care for adults with long-lasting depression.
Plain-language title generated from the registry record
Registry title: Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
Key facts
- Where
- Atlanta, Austin, Birmingham, Boston, Charleston, Chicago, Cleveland, Columbus, Dallas, Houston, Indianapolis, Los Angeles, Milwaukee, Minneapolis, New Brunswick, New York, Philadelphia, Rochester, Sacramento, Salt Lake City, St Louis, and Tampa, United StatesSee the 26 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 22 and 70 years old?
Source: NCT06423430, who can take part
Where in United States
- Emory University HospitalAtlanta, United StatesTaking people
- University of Texas Austin Dell Medical SchoolAustin, United StatesTaking people
- University of Alabama at Birmingham - Dept. of PsychiatryBirmingham, United StatesTaking people
- Beth Israel Deaconess Medical CenterBoston, United StatesTaking people
- Massachusetts General HospitalBoston, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Rush University Medical CenterChicago, United StatesTaking people
- University of ChicagoChicago, United StatesNot yet recruiting
- The Cleveland Clinic FoundationCleveland, United StatesTaking people
- The Ohio State UniversityColumbus, United StatesTaking people
- University of Texas Southwestern Medical Center at DallasDallas, United StatesTaking people
- CHI St. Luke's Health Baylor College of Medicine Med. Ctr.Houston, United StatesTaking people
- The Methodist HospitalHouston, United StatesTaking people
- Indiana UniversityIndianapolis, United StatesTaking people
- UCLA Department of PsychiatryLos Angeles, United StatesTaking people
- USC University HospitalLos Angeles, United StatesTaking people
- Medical College of WisconsinMilwaukee, United StatesTaking people
- University of Minnesota Medical Center, FairviewMinneapolis, United StatesTaking people
- Robert Wood Johnson University HospitalNew Brunswick, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesTaking people
- Pennsylvania HospitalPhiladelphia, United StatesTaking people
- Mayo ClinicRochester, United StatesTaking people
- University of California at DavisSacramento, United StatesTaking people
- University of Utah HospitalSalt Lake City, United StatesTaking people
- Washington University School of MedicineSt Louis, United StatesTaking people
- USF HealthTampa, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Abbott Medical Devices
- Trial code
- NCT06423430
- Record updated
- 16 October 2026
- Original description
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.Read full original descriptionShow less
Treatment ResistAnt Depression Subcallosal CingulatE Network DBS
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Inclusion: The patient must be diagnosed with non-psychotic unipolar Major Depressive Disorder; The patient must be in a major depressive episode for ≥12 months or have had at least 3 lifetime depressive episodes; The patient has tried and failed a minimum of four different types of antidepressant treatments as measured by a tool designed for this purpose; Depression medication and treatment regimen must be stable for a minimum of 4 weeks before the first baseline visit.
Exclusion: Current and ongoing use of neurostimulation treatment that may interfere with DBS therapy/system; Treatment with another investigational device or investigational drugs; Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that could limit participation in the study or interfere with adherence to the study protocol; Current or lifetime history of psychotic features in any Major Depressive Episode; Has an intracranial Central Nervous System disease that impairs motor, sensory or cognitive function or that requires intermittent or chronic medication; Diagnosis of Substance Use Disorder or Alcohol Use Disorder without sustained remission (12 months or longer); Pregnant or those who plan to become pregnant during study; Significant acute suicide risk.