Studies how insulin affects fasting blood sugar in people with prediabetes
Tests insulin and insulin pulses during fasting in adults with prediabetes.
Plain-language title generated from the registry record
Registry title: Insulin and Insulin Pulses During Fasting
Key facts
- Where
- Rochester, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 25 and 65 years old?
Source: NCT06424015, who can take part
Where in United States
- Mayo Clinic in RochesterRochester, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mayo Clinic
- Trial code
- NCT06424015
- Record updated
- 7 October 2026
- Original description
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.Read full original descriptionShow less
Effect of Insulin and Insulin Pulses on Fasting Glucagon Secretion and on Glucose Metabolism in Subjects Without Type 2 Diabetes
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
Inclusion: people with normal or impaired fasting glucose and normal or impaired glucose tolerance.
Exclusion: History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy; Active systemic illness or malignancy; Symptomatic macrovascular or microvascular disease; HbA1c > 6.5%; Use of any glucose-lowering agents including metformin or sulfonylureas; BMI ≥ 35 Kg/M2; For female subjects: positive pregnancy test at the time of enrollment or study; Hematocrit < 35%.