Under construction – not a live service
Sign in
Taking people in ItalyNo phase

Studying Diet-Related Sugar Products and Muscle Loss in Obesity

Observes whether skin levels of dietary AGEs relate to muscle loss in adults with obesity.

Key facts

Who runs it
Azienda Ospedaliero Universitaria Maggiore della Carita
Where
Novara, ItalySee the site
Trial code
Registry title
Investigating the Link Between Advanced Glycation End Products (AGEs) and Muscle Wasting in Sarcobesity
Status
Recruiting
People taking part
195 people, planned
Started
15 Jun 2024
Expected to end
15 May 2027
Type of study
Observational
Record updated
29 October 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with obesity and well-controlled type 2 diabetes, or with lipodystrophy. It studies how diet-related AGEs link to muscle loss.

Age
18 years or older
Sex
Women and men can join.
Disease stage
Obesity with type 2 diabetes in good metabolic control (HbA1c < 7.5% (58 mmol/mol)) within 15 years of entry into the study, or a diagnosis of lipodystrophy.
Biomarker or test result
HbA1c < 7.5% (58 mmol/mol) for people with type 2 diabetes.

Main reasons for not taking part

  • Under 18 years of age
  • Secondary obesity or genetic diseases such as Prader-Willi Syndrome or Down Syndrome
  • Metabolic or endocrine disorders such as Cushing's syndrome or hypothyroidism
  • Inflammatory Bowel Disease or cancer
  • Confirmed or planned pregnancy during the study

The registry criteria, word for word

Show all 7 criteriaShow less

Who can take part

  • Patients of both sexes
  • Adults
  • BMI compatible with obesity and a diagnosis of type 2 diabetes under good metabolic control (HbA1c < 7.5%) within 15 years of entry into the study or diagnosis of lipodystrophy (included in the European Consortium of Lipodystrophies (ECLip) Registry (eclip-web.org))

Who cannot take part

  • Secondary obesity or genetic diseases (Prader-Willi Syndrome, Down Syndrome); metabolic and endocrine disorders (Cushing's syndrome, hypothyroidism)
  • Subjects with: Inflammatory Bowel Disease (IBD), cancer
  • Age under 18 years
  • Confirmed or planned pregnancy during the study participation months

Where in Italy

  • SCDU Endocrinology, AOU Ospedale Maggiore della CaritàNovara, ItalyContact: Flavia ProdamTaking people

About the trial

What the trial wants to find out

The study aims to explore whether a high level of AGEs (Advanced Glycation end products) derived from the diet may mediate diet-related muscle loss in Western-type diet, influencing the onset and progression of sarcopenia, predisposing to earlier and more severe metabolic consequences, including type 2 diabetes (T2D).

Read full original descriptionShow less

The primary objective of the study is to investigate how the accumulation of AGEs is correlated with muscle loss in adult patients with obesity and type 2 diabetes or lipodystrophy in order to identify possible targets to mitigate the metabolic alterations caused by the Western diet (WD). Specifically, circulating AGEs levels on the skin will be evaluated and correlated with the stage of sarcopenia in a group of patients with obesity and a T2D diagnosis. Furthermore, the relationship between disease duration and AGE levels will be assessed.

A secondary objective will be to analyze the clinical data obtained to identify metabolites and metabolic pathways responsible for the phenotype induced by the WD.

The ultimate aim of the study is therefore to verify whether high levels of AGEs are correlated with an early and/or more pronounced onset of sarcopenia, concurrently with an increase in inflammation and oxidative stress.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Fighting Western-diet Derived AGEs to Mitigate Muscle Wasting in Sarcobesity:Observational Study on the Relationship Between AGE Levels and Sarcobesity in an Adult Population Affected by Obesity and Type 2 Diabetes Mellitus
Plain-language title
Studying Diet-Related Sugar Products and Muscle Loss in ObesityGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
29 October 2026