Using Gut Bacteria Samples to Predict Crohn's Disease Treatment Response
Studies whether gut bacteria patterns can predict treatment response in adults with Crohn's disease.
Plain-language title generated from the registry record
Registry title: Predicting IBD Treatment Outcomes With Gut Microbiome Analysis
Key facts
- Where
- Vancouver, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 19 and 80 years old?
Source: NCT06453720, who can take part
Where in Canada
- GI Research InstituteVancouver, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of British Columbia
- Trial code
- NCT06453720
- Record updated
- 20 January 2026
- Original description
The goal of this prospective observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn's disease (CD), a form of inflammatory bowel disease (IBD), living in British Columbia, Canada. The main questions this study seeks to answer are:Read full original descriptionShow less
Optimizing Patient Treatment Involving Microbiome Integration for Specialized Therapeutics
The goal of this prospective observational study is to determine if specific microbiome signatures can predict therapeutic responses in adult patients with Crohn's disease (CD), a form of inflammatory bowel disease (IBD), living in British Columbia, Canada. The main questions this study seeks to answer are:
1. Can microbiome signatures across different sample types (fecal, intestinal washings, and intestinal epithelial biopsies) predict response to therapy in CD? 2. How do microbiome profiles differ between active and quiescent CD and non-IBD controls?
Researchers will compare microbiome signatures in patients with active and inactive CD as well as non-IBD controls to see if there are any microbial signatures that predict response to therapy.
Participants will:
1. Provide fecal and blood samples. 2. Undergo intestinal washings and intestinal epithelial biopsy specimens taken during routine colonoscopy. 3. Participate in a longitudinal follow-up over 12 months to monitor clinical, biochemical, and endoscopic responses to therapy.
Inclusion: CD patients:; Adult patients ≥19 years old and ≤ 80 years old; CD with distal small bowel and/or colonic involvement that is endoscopically assessable with colonoscopy; Undergoing colonoscopy as part of routine clinical care; Active or quiescent disease; Active disease will be defined as a simple endoscopic score for CD (SES-CD); Quiescent disease is defined as an SES-CD <3; Mild active disease will be defined as a SES-CD of 3-6, or 3 with isolated ileal CD; Moderate/severe active disease will be defined as a simple endoscopic score for CD (SES-CD) ≥ 7 or ≥ 4 for isolated ileal CD; Non-IBD controls:; Adult patients ≥ 19 years old and ≤ 80 years old; Undergoing colonoscopy as part of colorectal screening.
Exclusion: Pouch, J-Pouch or Reversed pouch surgery; Bowel resection within the preceding 4 months; Previous bowel surgeries; Active perianal CD - defined as collection on MRI or clinically active fistula (i.e., draining fistula); Short Bowel Syndrome (SBS) diagnosis; Colorectal cancer, high-grade dysplasia or a polyp ≥2cm diagnosed at baseline endoscopy; History of IBD in 1st degree relative; CD patients:; Proximal small bowel (defined as not endoscopically assessable by colonoscopy) or isolated upper GI CD; Colectomy or Proctocolectomy; Antibiotics in the last 2 months for any indication; Gastroenteritis or travel outside of Canada and the United States in the last month; Pregnant or breastfeeding; Primary sclerosing cholangitis; Non-IBD controls:; Found to have inflammation (deemed by endoscopist) at colonoscopy; Antibiotics in the last 2 months; Gastroenteritis or travel outside of Canada and the United States in the last month; Pregnant or breastfeeding.