Quality of life and frailty in people starting home or in-center dialysis
Follows adults with advanced chronic kidney disease as they begin home or in-center dialysis.
Plain-language title generated from the registry record
Registry title: Quality of Life in Patients Transitioning to Home or In-Center Dialysis (QUALIFY CKD-to-HOME)
Key facts
- Where
- Montreal, CanadaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults followed in an advanced kidney disease clinic who are close to starting dialysis, at home or in a dialysis centre.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Advanced chronic kidney disease with eGFR ≤12 mL/min/1.73m2.
- Earlier treatment
- Must not have had dialysis for more than 3 months.
- Biomarker or test result
- eGFR ≤12 mL/min/1.73m2.
Main reasons for not taking part
- Planning conservative treatment (no dialysis)
- Planned kidney transplant in under 6 months
- Unable to give consent because of severe cognitive or psychiatric disease
- Dialysis for more than 3 months before
- Life expectancy under 6 months
Read by machine on 12 November 2026.
Where in Canada
- Hôpital Maisonneuve-RosemontMontreal, CanadaContact: Annie-Claire Nadeau-Fredette, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Ciusss de L'Est de l'Île de Montréal
- Trial code
- NCT06458322
- Record updated
- 23 February 2026
- Original description
The goal of this study is to evaluate quality of life (QoL) and frailty trajectories from advanced chronic kidney disease (CKD) to after dialysis initiation, specifically comparing patients choosing home dialysis and in-center hemodialysis.Read full original descriptionShow less
Prospective Changes in Quality of Life and Frailty in Chronic Kidney Disease Patients Transitioning to Home Versus In-Center Dialysis (QUALIFY CKD-to-HOME Study)
The goal of this study is to evaluate quality of life (QoL) and frailty trajectories from advanced chronic kidney disease (CKD) to after dialysis initiation, specifically comparing patients choosing home dialysis and in-center hemodialysis.
The main questions it aims to answer are:
1. What is the trajectory of QoL in patients transitioning from advanced CKD to dialysis (up to 12 months after initiation) and how does these changes differ for patients oriented towards home dialysis and in-center hemodialysis? 2. Is the development of frailty after dialysis initiation less likely in patient pursuing home dialysis? 3. What is the variation in other PROMs and health outcomes (fatigue, anxiety \& depression, general assessment, cognitive function) form advanced CKD to the first 12 months after dialysis initiation? 4. What are the predictors of severe decline in QoL, frailty and other important health outcomes (fatigue, cognition, anxiety \& depression) during CKD G5 follow-up and after 12 months post dialysis initiation?
Participants will be ask to:
* Answer some questions and complete questionnaires each 3 months; * Do a a grip test and a walking test each 6 months to evaluate their frailty;
Inclusion: Adult patients followed in advanced CKD clinic; eGFR ≤12 mL/min/1.73m2 96; Understand English or French.
Exclusion: Planned kidney transplantation < 6 months; Previous treatment with dialysis > 3 month; Unable to provide consent due to severe cognitive or psychiatric disease; Orientation toward conservative treatment; Life expectancy < 6 months.