Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement
Key facts
- Who runs it
- Istituto Ortopedico Rizzoli
- Where
- Bologna, ItalySee the site
- Trial code
- Status
- Recruiting
- People taking part
- 150 people, planned
- Started
- 12 Jan 2023
- Expected to end
- Oct 2027
- Type of study
- Observational, 2 groups
- Treatments tested
- High tibial osteotomy
- Record updated
- 29 January 2026
Who can take part
- Age
- 18 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Patients undergoing corrective knee osteotomy and any associated procedures such as meniscal repair/resection/replacement, ligament reconstruction, chondral treatment, or regenerative infiltrative treatment
- Patients aged between 18 and 70 years at the time of surgical intervention
- Patients with isolated compartmental osteoarthritis
- Patients with a varus or valgus knee alignment defect of at least 3° compared to mechanical neutrality
Who cannot take part
- Women of childbearing age who cannot exclude pregnancy
- Patients with advanced multicompartimental osteoarthritis
- Patients who are no longer reachable
- Patients unable to give informed consent or patients unwilling to sign the informed consent form
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Where in Italy
- IRCCS Istituto ortopedico RizzoliBologna, ItalyContact: Stefano ZaffagniniTaking people
About the trial
What the trial wants to find out
The present study aims to evaluate the long-term and medium-term outcomes of different knee osteotomy techniques in the treatment of knee osteoarthritis in patients with lower limb malalignment. This evaluation is necessary in the current context of research on the treatment and prevention of knee osteoarthritis through treatments that do not involve or allow for the postponement of prosthetic replacement. Among the biological treatments performed in orthopedic clinical practice, osteotomy is one of the most promising. However, further long-term evaluations are needed to more clearly determine the indications and potential of this type of intervention, considering the various surgical procedures described for performing it.
The 2 groups in the trial
- Closing wedge
Patients undergoing closing wedge high tibial osteotomy in knee ostheoarthritis and lower limb malalignement
Treatment: High tibial osteotomy
- Opening wedge
Patients undergoing opening wedge high tibial osteotomy in knee ostheoarthritis and lower limb malalignement
Treatment: High tibial osteotomy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Long-term Clinical and Radiographic Outcomes of Different Knee Osteotomy Techniques for the Treatment of Compartmental Knee Osteoarthritis With Lower Limb Malalignment.
- Fit questions
- Built from NCT06462625, who can take part
- Record updated
- 29 January 2026