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Screening adults for MGUS and studying genetic and immune factors

Screens adults aged 40 and older for an abnormal blood protein called MGUS.

Plain-language title generated from the registry record
Registry title: MGUS/MM Awareness and Genetics Insights Campaign (MAGIC) Screening Study

Key facts

Where
Rochester, United StatesSee the site

Where in United States

  • Mayo Clinic in RochesterRochester, United StatesNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
Mayo Clinic
Trial code
NCT06472830
Record updated
11 August 2026
Original description
This study is being done to screen adults for MGUS and to better understand the genetic and immune factors linked to this condition. Monoclonal gammopathy of undetermined significance or MGUS is a condition where an abnormal immune protein is found in the blood. MGUS is not cancer. In some people, it slowly develops into a blood cancer called multiple myeloma. MGUS occurs in people from all backgrounds. Researchers hope to use the information from this study to improve knowledge, early detection, and future care for everyone.Read full original descriptionShow less

Monoclonal Gammopathy of Undetermined Significance (MGUS) /Myeloma Awareness and Genetic Insights Campaign (MAGIC) Screening Study

This study is being done to screen adults for MGUS and to better understand the genetic and immune factors linked to this condition. Monoclonal gammopathy of undetermined significance or MGUS is a condition where an abnormal immune protein is found in the blood. MGUS is not cancer. In some people, it slowly develops into a blood cancer called multiple myeloma. MGUS occurs in people from all backgrounds. Researchers hope to use the information from this study to improve knowledge, early detection, and future care for everyone.

Inclusion: Adults ≥ 40 years; Willing and able to review, understand, and provide consent before starting any study-specific procedures; Ability to complete questionnaire(s) by themselves or with assistance.

Exclusion: Pregnant women.

ClinicalTrials.gov NCT06472830