Comparing two targeted medicines for thyroid cancer that stopped responding to treatment
Tests cabozantinib against dabrafenib with trametinib in adults with BRAF-mutated thyroid cancer.
Plain-language title generated from the registry record
Registry title: Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer
Key facts
- Where
- Aberdeen, Allentown, Alma, Alpena, Alton, Anaconda, Anchorage, Ankeny, Ann Arbor, Atlanta, Aurora, Baker City, Ballwin, Baltimore, Barrington, Bellingham, Bemidji, Bend, Bethlehem, Bettendorf, Billings, Bismarck, Boise, Bolivar, Bozeman, Branson, Brighton, Burbank, Burlington, Burnsville, Caldwell, Cambridge, Canton, Cape Girardeau, Caro, Carroll, Cary, Cedar Rapids, Centralia, Chapel Hill, Charleston, Chaska, Chelsea, Cheyenne, Chicago, City of Saint Peters, Clackamas, Clarkston, Clive, Cody, Coeur d'Alene, Coon Rapids, Coos Bay, Council Bluffs, Creston, Creve Coeur, Crown Point, Crystal Lake, Cudahy, DeKalb, Derby, Des Moines, Detroit, Downers Grove, Durham, East China, East Stroudsburg, Eau Claire, Edina, Edmonds, Elgin, Emmett, Erie, Everett, Fairbanks, Fairfield, Fargo, Flint, Fort Dodge, Fort Lauderdale, Fort Smith, Franklin, Fruitland, Garden City, Geneva, Germantown, Gladwin, Glastonbury, Glenview, Grafton, Grand Rapids, Grayslake, Great Bend, Great Falls, Green Bay, Greenwich, Grosse Pointe Woods, Guilford, Hartford, Havre, Hazel Crest, Hazleton, Helena, Highlands Ranch, Hood River, Iowa City, Irvine, Issaquah, Jacksonville, Joplin, Kalispell, Kennewick, Kenosha, Lacey, Lake Forest, Lansing, Lawton, Lexington, Libertyville, Little Rock, Livonia, Longview, Macomb, Maple Grove, Maplewood, Marinette, Marlette, Marshfield, Meridian, Midland, Milwaukee, Minneapolis, Minocqua, Missoula, Monticello, Mount Pleasant, Mount Vernon, Muskegon, Nampa, Napa, Nashville, New Haven, New Lenox, New Richmond, New Ulm, Newberg, North Haven, Norton Shores, Oak Lawn, Oklahoma City, Omaha, Ontario, Orange, Oregon City, Orland Park, Osage Beach, Oshkosh, Palo Alto, Palos Heights, Park Ridge, Pella, Philadelphia, Pittsburg, Pittsburgh, Pontiac, Portland, Post Falls, Princeton, Racine, Raleigh, Redmond, Rice Lake, Robbinsdale, Rochester, Rolla, Saginaw, Saint Joseph, Saint Louis Park, Saint Paul, Salt Lake City, Sandpoint, Santa Rosa, Seattle, Sedro-Woolley, Shakopee, Sheboygan, Sheridan, Shiloh, Sioux Falls, Spokane, Springfield, St Louis, Stamford, Stevens Point, Stillwater, Summit, Tawas City, Thief River Falls, Torrington, Trumbull, Twin Falls, Two Rivers, Vancouver, Waconia, Walla Walla, Warren, Warrenville, Washington, Waterbury, Waterford, Waukee, Wauwatosa, West Allis, West Branch, West Des Moines, Westerly, Weston, Willmar, Woodbury, Worthington, Wyoming, and Ypsilanti, United StatesSee the 307 sites
- Phase
- Phase 3
Where in United States
- Providence Regional Cancer System-AberdeenAberdeen, United StatesTaking people
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
- MyMichigan Medical Center GratiotAlma, United StatesTaking people
- MyMichigan Medical Center AlpenaAlpena, United StatesTaking people
- OSF Saint Anthony's Health CenterAlton, United StatesTaking people
- Community Hospital of AnacondaAnaconda, United StatesTaking people
- Alaska Breast Care and Surgery LLCAnchorage, United StatesTaking people
- Alaska Oncology and Hematology LLCAnchorage, United StatesTaking people
- Alaska Women's Cancer CareAnchorage, United StatesTaking people
- Anchorage Associates in Radiation MedicineAnchorage, United StatesTaking people
- Katmai Oncology GroupAnchorage, United StatesTaking people
- Providence Alaska Medical CenterAnchorage, United StatesTaking people
- Anchorage Radiation Therapy CenterAnchorage, United StatesNo longer taking part
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
- Trinity Health IHA - Obstetrics and Gynecology West ArborAnn Arbor, United StatesTaking people
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, United StatesTaking people
- University of Michigan Rogel Cancer CenterAnn Arbor, United StatesTaking people
- Emory University Hospital MidtownAtlanta, United StatesTaking people
- Advocate Outpatient Center - AuroraAurora, United StatesTaking people
- UCHealth University of Colorado HospitalAurora, United StatesTaking people
- Saint Alphonsus Cancer Care Center-Baker CityBaker City, United StatesTaking people
- Mercy Oncology and Hematology - Clayton-ClarksonBallwin, United StatesTaking people
- University of Maryland/Greenebaum Cancer CenterBaltimore, United StatesTaking people
- Advocate Good Shepherd HospitalBarrington, United StatesTaking people
- PeaceHealth Saint Joseph Medical CenterBellingham, United StatesTaking people
- Sanford Joe Lueken Cancer CenterBemidji, United StatesTaking people
- Saint Charles Health SystemBend, United StatesTaking people
- Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesTaking people
- University of Iowa Healthcare Cancer Services Quad CitiesBettendorf, United StatesTaking people
- Billings Clinic Cancer CenterBillings, United StatesTaking people
- Sanford Bismarck Medical CenterBismarck, United StatesTaking people
- Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesTaking people
- Saint Luke's Cancer Institute - BoiseBoise, United StatesTaking people
- Central Care Cancer Center - BolivarBolivar, United StatesTaking people
- Bozeman Health Deaconess HospitalBozeman, United StatesTaking people
- Cox Cancer Center BransonBranson, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
- Trinity Health Medical Center - BrightonBrighton, United StatesTaking people
- University of Michigan - Brighton Center for Specialty CareBrighton, United StatesTaking people
- Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, United StatesTaking people
- Aurora Cancer Care-Southern Lakes VLCCBurlington, United StatesTaking people
- Minnesota Oncology - BurnsvilleBurnsville, United StatesTaking people
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesTaking people
- Cambridge Medical CenterCambridge, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
- Trinity Health Medical Center - CantonCanton, United StatesTaking people
- Mercy Cancer Center - Cape GirardeauCape Girardeau, United StatesTaking people
- Caro Cancer CenterCaro, United StatesNo longer taking part
- Saint Anthony Regional HospitalCarroll, United StatesTaking people
- Duke Cancer Center CaryCary, United StatesNo longer taking part
- Mercy HospitalCedar Rapids, United StatesTaking people
- Oncology Associates at Mercy Medical CenterCedar Rapids, United StatesTaking people
- Providence Regional Cancer System-CentraliaCentralia, United StatesTaking people
- Saint Mary's HospitalCentralia, United StatesNo longer taking part
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Minnesota Oncology Hematology PA-ChaskaChaska, United StatesTaking people
- Chelsea HospitalChelsea, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
- Memorial Hospital of Laramie CountyCheyenne, United StatesTaking people
- Advocate Illinois Masonic Medical CenterChicago, United StatesTaking people
- Northwestern UniversityChicago, United StatesTaking people
- University of Chicago Comprehensive Cancer CenterChicago, United StatesTaking people
- University of IllinoisChicago, United StatesTaking people
- Siteman Cancer Center at Saint Peters HospitalCity of Saint Peters, United StatesTaking people
- Clackamas Radiation Oncology CenterClackamas, United StatesTaking people
- Providence Cancer Institute Clackamas ClinicClackamas, United StatesNo longer taking part
- Hematology Oncology Consultants-ClarkstonClarkston, United StatesTaking people
- Trinity Health IHA Medical Group - Primary Care - ClarkstonClarkston, United StatesTaking people
- Newland Medical Associates-ClarkstonClarkston, United StatesNo longer taking part
- Mercy Cancer Center-West LakesClive, United StatesTaking people
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
- Billings Clinic-CodyCody, United StatesTaking people
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- Minnesota Oncology - Coon RapidsCoon Rapids, United StatesTaking people
- Bay Area HospitalCoos Bay, United StatesTaking people
- Heartland Oncology and Hematology LLPCouncil Bluffs, United StatesTaking people
- Methodist Jennie Edmundson HospitalCouncil Bluffs, United StatesTaking people
- Nebraska Cancer Specialists/Oncology Hematology West PC - MEJCouncil Bluffs, United StatesTaking people
- Greater Regional Medical CenterCreston, United StatesTaking people
- Siteman Cancer Center at West County HospitalCreve Coeur, United StatesTaking people
- UChicago Medicine Northwest IndianaCrown Point, United StatesTaking people
- AMG Crystal Lake - OncologyCrystal Lake, United StatesTaking people
- Aurora Saint Luke's South ShoreCudahy, United StatesTaking people
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesTaking people
- Smilow Cancer Hospital-Derby Care CenterDerby, United StatesTaking people
- Broadlawns Medical CenterDes Moines, United StatesTaking people
- Iowa Methodist Medical CenterDes Moines, United StatesTaking people
- Mercy Medical Center - Des MoinesDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
- Henry Ford Health Saint John HospitalDetroit, United StatesTaking people
- Advocate Good Samaritan HospitalDowners Grove, United StatesTaking people
- Duke University Medical CenterDurham, United StatesTaking people
- Henry Ford River District HospitalEast China, United StatesTaking people
- Pocono Medical CenterEast Stroudsburg, United StatesTaking people
- Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
- Fairview Southdale HospitalEdina, United StatesTaking people
- Minnesota Oncology - EdinaEdina, United StatesTaking people
- Swedish Cancer Institute-EdmondsEdmonds, United StatesTaking people
- Advocate Sherman HospitalElgin, United StatesTaking people
- Walter Knox Memorial HospitalEmmett, United StatesNo longer taking part
- UPMC Hillman Cancer Center ErieErie, United StatesTaking people
- Providence Regional Cancer PartnershipEverett, United StatesTaking people
- Fairbanks Memorial HospitalFairbanks, United StatesTaking people
- Smilow Cancer Hospital Care Center-FairfieldFairfield, United StatesTaking people
- Sanford Broadway Medical CenterFargo, United StatesTaking people
- Sanford Medical Center FargoFargo, United StatesTaking people
- Sanford Roger Maris Cancer CenterFargo, United StatesTaking people
- Sanford South University Medical CenterFargo, United StatesTaking people
- Southpointe-Sanford Medical Center FargoFargo, United StatesTaking people
- Cancer Hematology Centers - FlintFlint, United StatesTaking people
- Genesee Hematology Oncology PCFlint, United StatesTaking people
- Genesys Hurley Cancer InstituteFlint, United StatesTaking people
- Hurley Medical CenterFlint, United StatesTaking people
- UI Healthcare Mission Cancer and Blood - Fort DodgeFort Dodge, United StatesTaking people
- Holy Cross HospitalFort Lauderdale, United StatesTaking people
- Mercy Hospital Fort SmithFort Smith, United StatesTaking people
- Vanderbilt-Ingram Cancer Center Cool SpringsFranklin, United StatesNo longer taking part
- Saint Luke's Cancer Institute - FruitlandFruitland, United StatesTaking people
- Central Care Cancer Center - Garden CityGarden City, United StatesTaking people
- Northwestern Medicine Cancer Center DelnorGeneva, United StatesTaking people
- Aurora Health Care Germantown Health CenterGermantown, United StatesTaking people
- MyMichigan Medical Center GladwinGladwin, United StatesTaking people
- Smilow Cancer Hospital Care Center at GlastonburyGlastonbury, United StatesTaking people
- Northwestern Medicine Glenview Outpatient CenterGlenview, United StatesTaking people
- Aurora Cancer Care-GraftonGrafton, United StatesTaking people
- Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
- Northwestern Medicine Grayslake Outpatient CenterGrayslake, United StatesTaking people
- Central Care Cancer Center - Great BendGreat Bend, United StatesTaking people
- Benefis Sletten Cancer InstituteGreat Falls, United StatesTaking people
- Great Falls ClinicGreat Falls, United StatesTaking people
- Aurora BayCare Medical CenterGreen Bay, United StatesTaking people
- Smilow Cancer Hospital Care Center at GreenwichGreenwich, United StatesTaking people
- Henry Ford Saint John Hospital - AcademicGrosse Pointe Woods, United StatesTaking people
- Henry Ford Saint John Hospital - BreastGrosse Pointe Woods, United StatesTaking people
- Henry Ford Saint John Hospital - Van ElslanderGrosse Pointe Woods, United StatesTaking people
- Smilow Cancer Hospital Care Center - GuilfordGuilford, United StatesTaking people
- Smilow Cancer Hospital Care Center at Saint FrancisHartford, United StatesTaking people
- Hi-Line Sletten Cancer CenterHavre, United StatesTaking people
- Advocate South Suburban HospitalHazel Crest, United StatesTaking people
- Lehigh Valley Hospital-HazletonHazleton, United StatesTaking people
- Benefis Helena Specialty CenterHelena, United StatesTaking people
- UCHealth Highlands Ranch HospitalHighlands Ranch, United StatesTaking people
- Providence Hood River Memorial HospitalHood River, United StatesTaking people
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesTaking people
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, United StatesTaking people
- Swedish Cancer Institute-IssaquahIssaquah, United StatesTaking people
- Mayo Clinic in FloridaJacksonville, United StatesNo longer taking part
- Freeman Health SystemJoplin, United StatesTaking people
- Mercy Hospital JoplinJoplin, United StatesTaking people
- Logan Health Medical CenterKalispell, United StatesTaking people
- Kadlec Clinic Hematology and OncologyKennewick, United StatesTaking people
- Aurora Cancer Care-Kenosha SouthKenosha, United StatesTaking people
- Providence Regional Cancer System-LaceyLacey, United StatesTaking people
- Northwestern Medicine Lake Forest HospitalLake Forest, United StatesTaking people
- University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
- Cancer Centers of Southwest Oklahoma ResearchLawton, United StatesTaking people
- University of Kentucky/Markey Cancer CenterLexington, United StatesTaking people
- AMG Libertyville - OncologyLibertyville, United StatesTaking people
- Condell Memorial HospitalLibertyville, United StatesTaking people
- CARTI Cancer CenterLittle Rock, United StatesTaking people
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- PeaceHealth Saint John Medical CenterLongview, United StatesTaking people
- Henry Ford Saint John Hospital - Macomb MedicalMacomb, United StatesTaking people
- Henry Ford Warren Hospital - Breast MacombMacomb, United StatesTaking people
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, United StatesTaking people
- Minnesota Oncology - Maple GroveMaple Grove, United StatesTaking people
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesTaking people
- Saint John's Hospital - HealtheastMaplewood, United StatesTaking people
- Aurora Bay Area Medical Group-MarinetteMarinette, United StatesTaking people
- Saint Mary's Oncology/Hematology Associates of MarletteMarlette, United StatesNo longer taking part
- Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
- Idaho Urologic Institute-MeridianMeridian, United StatesTaking people
- Saint Luke's Cancer Institute - MeridianMeridian, United StatesTaking people
- MyMichigan Medical Center MidlandMidland, United StatesTaking people
- Aurora Cancer Care-MilwaukeeMilwaukee, United StatesTaking people
- Aurora Saint Luke's Medical CenterMilwaukee, United StatesTaking people
- Aurora Sinai Medical CenterMilwaukee, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
- Health Partners IncMinneapolis, United StatesTaking people
- Hennepin County Medical CenterMinneapolis, United StatesTaking people
- Marshfield Medical Center - MinocquaMinocqua, United StatesTaking people
- Community Medical CenterMissoula, United StatesTaking people
- Saint Patrick Hospital - Community HospitalMissoula, United StatesTaking people
- Monticello Cancer CenterMonticello, United StatesTaking people
- MyMichigan Medical Center Mount PleasantMount Pleasant, United StatesTaking people
- Skagit Regional Health Cancer Care CenterMount Vernon, United StatesTaking people
- SSM Health Good SamaritanMount Vernon, United StatesTaking people
- Trinity Health Muskegon HospitalMuskegon, United StatesTaking people
- Saint Alphonsus Cancer Care Center-NampaNampa, United StatesTaking people
- Saint Luke's Cancer Institute - NampaNampa, United StatesTaking people
- Providence Queen of The ValleyNapa, United StatesTaking people
- Vanderbilt Breast Center at One Hundred OaksNashville, United StatesTaking people
- Vanderbilt University/Ingram Cancer CenterNashville, United StatesTaking people
- Smilow Cancer Center/Yale-New Haven HospitalNew Haven, United StatesTaking people
- Yale UniversityNew Haven, United StatesTaking people
- UC Comprehensive Cancer Center at Silver CrossNew Lenox, United StatesTaking people
- Cancer Center of Western WisconsinNew Richmond, United StatesTaking people
- New Ulm Medical CenterNew Ulm, United StatesTaking people
- Providence Newberg Medical CenterNewberg, United StatesTaking people
- Yale-New Haven Hospital North Haven Medical CenterNorth Haven, United StatesTaking people
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesTaking people
- Advocate Christ Medical CenterOak Lawn, United StatesTaking people
- Advocate Outpatient Center - Oak LawnOak Lawn, United StatesTaking people
- Mercy Hospital Oklahoma CityOklahoma City, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECCOmaha, United StatesTaking people
- Nebraska Methodist HospitalOmaha, United StatesTaking people
- Oncology Associates PCOmaha, United StatesNo longer taking part
- Saint Alphonsus Cancer Care Center-OntarioOntario, United StatesTaking people
- UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, United StatesTaking people
- Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
- Northwestern Medicine Orland ParkOrland Park, United StatesTaking people
- University of Chicago Medicine-Orland ParkOrland Park, United StatesTaking people
- Lake Regional HospitalOsage Beach, United StatesTaking people
- Vince Lombardi Cancer Clinic - OshkoshOshkosh, United StatesTaking people
- Stanford Cancer Institute Palo AltoPalo Alto, United StatesTaking people
- Advocate High Tech Medical ParkPalos Heights, United StatesTaking people
- Advocate Lutheran General HospitalPark Ridge, United StatesTaking people
- UI Healthcare Mission Cancer and Blood - PellaPella, United StatesTaking people
- University of Pennsylvania/Abramson Cancer CenterPhiladelphia, United StatesTaking people
- Mercy Hospital PittsburgPittsburg, United StatesTaking people
- UPMC Hillman Cancer CenterPittsburgh, United StatesTaking people
- Michigan Healthcare Professionals PontiacPontiac, United StatesTaking people
- Newland Medical Associates-PontiacPontiac, United StatesTaking people
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesTaking people
- Hope Cancer CenterPontiac, United StatesNo longer taking part
- Providence Portland Medical CenterPortland, United StatesTaking people
- Providence Saint Vincent Medical CenterPortland, United StatesTaking people
- Oregon Health and Science UniversityPortland, United StatesNo longer taking part
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesTaking people
- Fairview Northland Medical CenterPrinceton, United StatesTaking people
- Aurora Cancer Care-RacineRacine, United StatesTaking people
- Duke Cancer Center RaleighRaleigh, United StatesNo longer taking part
- Saint Charles Health System-RedmondRedmond, United StatesTaking people
- Marshfield Medical Center-Rice LakeRice Lake, United StatesTaking people
- North Memorial Medical Health CenterRobbinsdale, United StatesTaking people
- Mayo Clinic in RochesterRochester, United StatesNo longer taking part
- Mercy Clinic-Rolla-Cancer and HematologyRolla, United StatesTaking people
- Phelps Health Delbert Day Cancer InstituteRolla, United StatesTaking people
- MyMichigan Medical Center SaginawSaginaw, United StatesTaking people
- Oncology Hematology Associates of Saginaw Valley PCSaginaw, United StatesNo longer taking part
- Heartland Regional Medical CenterSaint Joseph, United StatesTaking people
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- United HospitalSaint Paul, United StatesTaking people
- Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesTaking people
- Kootenai Clinic Cancer Services - SandpointSandpoint, United StatesTaking people
- Providence Medical Foundation - Santa RosaSanta Rosa, United StatesTaking people
- Providence Santa Rosa Memorial HospitalSanta Rosa, United StatesTaking people
- Swedish Medical Center-Ballard CampusSeattle, United StatesTaking people
- Swedish Medical Center-Cherry HillSeattle, United StatesTaking people
- Swedish Medical Center-First HillSeattle, United StatesTaking people
- PeaceHealth United General Medical CenterSedro-Woolley, United StatesTaking people
- Saint Francis Regional Medical CenterShakopee, United StatesTaking people
- Vince Lombardi Cancer Clinic-SheboyganSheboygan, United StatesTaking people
- Welch Cancer CenterSheridan, United StatesNo longer taking part
- Memorial Hospital EastShiloh, United StatesTaking people
- Sanford Cancer Center Oncology ClinicSioux Falls, United StatesTaking people
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesTaking people
- Cancer Care Northwest - Spokane SouthSpokane, United StatesTaking people
- Cancer Care Northwest-North SpokaneSpokane, United StatesTaking people
- Cancer Care Northwest-ValleySpokane, United StatesTaking people
- CoxHealth South HospitalSpringfield, United StatesTaking people
- Mercy Hospital SpringfieldSpringfield, United StatesTaking people
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Mercy Hospital SouthSt Louis, United StatesTaking people
- Mercy Infusion Center - ChippewaSt Louis, United StatesTaking people
- Siteman Cancer Center at Christian HospitalSt Louis, United StatesTaking people
- Siteman Cancer Center-South CountySt Louis, United StatesTaking people
- Washington University School of MedicineSt Louis, United StatesTaking people
- Smilow Cancer Hospital Care Center at Long RidgeStamford, United StatesTaking people
- Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
- Lakeview HospitalStillwater, United StatesTaking people
- Aurora Medical Center in SummitSummit, United StatesTaking people
- MyMichigan Medical Center TawasTawas City, United StatesTaking people
- Sanford Thief River Falls Medical CenterThief River Falls, United StatesTaking people
- Smilow Cancer Hospital-Torrington Care CenterTorrington, United StatesTaking people
- Smilow Cancer Hospital Care Center-TrumbullTrumbull, United StatesTaking people
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, United StatesTaking people
- Vince Lombardi Cancer Clinic-Two RiversTwo Rivers, United StatesTaking people
- PeaceHealth Southwest Medical CenterVancouver, United StatesTaking people
- Ridgeview Medical CenterWaconia, United StatesTaking people
- Providence Saint Mary Regional Cancer CenterWalla Walla, United StatesTaking people
- Henry Ford Health Warren HospitalWarren, United StatesTaking people
- Henry Ford Madison Heights Hospital - BreastWarren, United StatesTaking people
- Henry Ford Warren Hospital - GLCMSWarren, United StatesTaking people
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesTaking people
- Mercy Hospital WashingtonWashington, United StatesTaking people
- Smilow Cancer Hospital-Waterbury Care CenterWaterbury, United StatesTaking people
- Smilow Cancer Hospital Care Center - WaterfordWaterford, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, United StatesTaking people
- Aurora Cancer Care-Milwaukee WestWauwatosa, United StatesTaking people
- Aurora West Allis Medical CenterWest Allis, United StatesTaking people
- Saint Mary's Oncology/Hematology Associates of West BranchWest Branch, United StatesNo longer taking part
- Mercy Medical Center-West LakesWest Des Moines, United StatesTaking people
- The Iowa Clinic PCWest Des Moines, United StatesTaking people
- Smilow Cancer Hospital Care Center - WesterlyWesterly, United StatesTaking people
- Marshfield Medical Center - WestonWeston, United StatesTaking people
- Rice Memorial HospitalWillmar, United StatesTaking people
- Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesTaking people
- Sanford Cancer Center WorthingtonWorthington, United StatesTaking people
- Fairview Lakes Medical CenterWyoming, United StatesTaking people
- Huron Gastroenterology PCYpsilanti, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- ECOG-ACRIN Cancer Research Group
- Trial code
- NCT06475989
- Record updated
- 24 September 2026
- Original description
This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth of tumor cells and blood vessels the tumor needs to survive. Dabrafenib is an enzyme inhibitor that binds to and inhibits the activity of a protein called B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. Trametinib is also an enzyme inhibitor. It binds to and inhibits the activity of proteins called MEK 1 and 2, which play a key role in activating pathways that regulate cell growth. This may inhibit the growth of tumor cells mediated by these pathways. The usual approach for patients with thyroid cancer is targeted therapy with dabrafenib and trametinib. This trial may help researchers decide which treatment option (cabozantinib alone or dabrafenib in combination with trametinib) is safer and/or more effective in treating patients with refractory BRAF V600E-mutated differentiated thyroid cancer.Read full original descriptionShow less
A Randomized Phase III Study of BRAF-Targeted Therapy vs Cabozantinib in RAI-Refractory Differentiated Thyroid Cancer With BRAF V600Em
This phase III trial compares the effect of cabozantinib versus combination dabrafenib and trametinib for the treatment of patients with differentiated thyroid cancer that does not respond to treatment (refractory) and which expresses a BRAF V600E mutation. Cabozantinib is in a class of medications called receptor tyrosine kinase inhibitors. It binds to and blocks the action of several enzymes which are often over-expressed in a variety of tumor cell types. This may help stop or slow the growth of tumor cells and blood vessels the tumor needs to survive. Dabrafenib is an enzyme inhibitor that binds to and inhibits the activity of a protein called B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. Trametinib is also an enzyme inhibitor. It binds to and inhibits the activity of proteins called MEK 1 and 2, which play a key role in activating pathways that regulate cell growth. This may inhibit the growth of tumor cells mediated by these pathways. The usual approach for patients with thyroid cancer is targeted therapy with dabrafenib and trametinib. This trial may help researchers decide which treatment option (cabozantinib alone or dabrafenib in combination with trametinib) is safer and/or more effective in treating patients with refractory BRAF V600E-mutated differentiated thyroid cancer.
Inclusion: Patient must be ≥ 18 years of age; Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-2; Patient must have differentiated thyroid cancer (DTC) with BRAF V600E mutation as determined by local testing, including the following subtypes (Note: results of a previous biopsy will be accepted):; Papillary thyroid carcinoma including histological variants of papillary thyroid carcinoma (PTC) such as follicular variant, tall cell, columnar cell, cribriform-morular, solid, oxyphil, Warthin-like, trabecular, tumor with nodular fasciitis-like stroma, Hürthle cell variant of papillary carcinoma, poorly differentiated; Follicular thyroid carcinoma including histological variants of follicular thyroid carcinoma (FTC) such as Hürthle cell, clear cell, insular, and poorly differentiated; Patient must have been previously treated with or deemed ineligible for treatment with Iodine-131 for DTC, and must be receiving thyroxine suppression therapy; Patient must have had prior treatment with at least one of the following vascular endothelial growth factor receptors (VEGFR)-targeting tyrosine kinase inhibitor (TKI) agents for DTC: lenvatinib or sorafenib; NOTE: Up to two prior VEGFR-targeting TKI agents are allowed including, but not limited to lenvatinib and sorafenib; Patient must have measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) 1·1 on chest CT (computed tomography)/abdominal/pelvis CT/MRI (magnetic resonance imaging) performed within 4 weeks prior to randomization; Patient must have radiographic progression by RECIST 1.1 over any time interval on or after most recent prior systemic treatment; Patient must not have any of the following cardiovascular and thromboembolic disorders or medical conditions:; Congestive heart failure class 3 or 4 as defined by the New York Heart Association, unstable angina pectoris, or serious cardiac arrhythmias; Uncontrolled hypertension defined as sustained blood pressure > 150 mm Hg systolic or > 100 mm Hg diastolic despite optimal antihypertensive treatment; Stroke, myocardial infarction, or thromboembolic event (e.g., deep venous thrombosis, pulmonary embolism) within 6 months prior to randomization. Patients with more recent diagnosis of deep venous thrombosis are allowed if stable and treated with therapeutic anticoagulation for at least 6 weeks prior to randomization; Patient must not have any clinically significant hematemesis or haemoptysis of > 0·5 teaspoon (> 2·5 mL) of red blood or history of other significant bleeding within 3 months prior to randomization; Patient must not have any cavitating pulmonary lesion(s) or lesions invading major pulmonary blood vessels; Patient must not be on any concomitant anticoagulation with oral anticoagulants or platelet inhibitors, except for the following allowed agents:; Low-dose aspirin for cardioprotection; Therapeutic anticoagulation with any agent in patients (1) without known brain metastases, (2) on a stable dose for at least 6 weeks prior to randomization, and (3) with no clinically significant hemorrhagic complications from the anticoagulation regimen or the tumor; Patient must not have any gastrointestinal (GI) disorders associated with a high risk of perforation or fistula formation:; Tumors invading the GI tract, active peptic ulcer disease, inflammatory bowel disease, ulcerative colitis, diverticulitis, cholecystitis, symptomatic cholangitis or appendicitis, acute pancreatitis, or acute obstruction of the pancreatic or biliary duct, or gastric outlet obstruction; Abdominal fistula, GI perforation, bowel obstruction, or intra-abdominal abscess within 6 months prior to randomization; Patient must have completed any prior local therapy (e.g., surgery, radiation, ablation) at least 4 weeks prior to randomization, with complete wound healing and resolution of clinically relevant complications from prior local therapy; Patient must not have had major surgery (e.g., GI surgery, removal or biopsy of brain metastasis) within 8 weeks prior to randomization. Complete wound healing from major surgery must have occurred 4 weeks prior to randomization and from minor surgery (e.g., simple excision, tooth extraction) at least 10 days prior to randomization; Patient must not have pathologically documented anaplastic histology or transformation on any recurrence specimen collected after initial thyroidectomy/neck dissection; Patient must not have had prior treatment with cabozantinib or any prior BRAF targeted therapy for thyroid cancer; NOTE: Prior treatment with checkpoint inhibitor (e.g., pembrolizumab) for thyroid cancer is allowed, but must be noted on the eCRF (electronic case report form); Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used; All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy; A patient of childbearing potential is defined as someone, regardless of whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months); Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study and for 2 weeks after the last dose of dabrafenib and 4 months after the last dose of trametinib or cabozantinib. Patients must also not breastfeed while on study treatment and for 2 weeks after the last dose of dabrafenib and for 4 months after the last dose of trametinib or cabozantinib; NOTE: Patients of childbearing potential who are on hormonal contraceptives may be at risks because dabrafenib may decrease the efficacy of hormonal contraceptives. An effective non-hormonal contraception should be used during therapy and for 2 weeks following discontinuation of dabrafenib and at least 4 months following the last dose of trametinib and cabozantinib; Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible; Hemoglobin (Hgb) ≥ 8 g/dL obtained ≤ 28 days prior to protocol randomization; Leukocytes ≥ 3,000/mcL obtained ≤ 28 days prior to protocol randomization; Absolute neutrophil count (ANC) ≥ 1,500/mcL obtained ≤ 28 days prior to protocol randomization; Platelets ≥ 100,000/mcL obtained ≤ 28 days prior to protocol randomization; Total bilirubin ≤ 2.0 x institutional upper limit of normal (ULN) obtained ≤ 28 days prior to protocol randomization; Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamic pyruvic transaminase [SGPT]) ≤ 3.0 × institutional ULN or < 5.0 x ULN with the presence of hepatic metastasis obtained ≤ 28 days prior to protocol randomization; Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m² obtained ≤ 28 days prior to protocol randomization; Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial; For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated; Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load; Patients with treated brain metastases are eligible if follow-up brain imaging obtained after central nervous system (CNS)-directed therapy (radiotherapy and/or surgery) shows no evidence of progression. CNS disease must be stable for at least 4 weeks prior to randomization; patients must be neurologically asymptomatic and without corticosteroid treatment at time of randomization; Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial; Patients must have corrected QT interval calculated by the Fridericia formula (QTcF) ≤ 500 ms obtained within 28 days prior to randomization; NOTE: If a single electrocardiogram (ECG) shows a QTcF with an absolute value > 500 ms, two additional ECGs at intervals of approximately 3 minutes (min) must be performed within 30 min after the initial ECG, and the average of these 3 consecutive results for QTcF will be used to determine eligibility; Patient must be English or Spanish speaking to be eligible for the quality of life (QOL) component of the study; NOTE: Sites cannot translate the associated QOL forms.