Homologus PRP in the Infiltrative Treatment of Knee Osteoarthritis in Young Athletic Patients
Key facts
- Who runs it
- Istituto Ortopedico Rizzoli
- Where
- Bologna, ItalySee the site
- Trial code
- Status
- Recruiting
- People taking part
- 30 people, planned
- Started
- 10 Oct 2023
- Planned end
- Sept 2026
- Type of study
- Interventional
- Treatments tested
- PRP infiltration
- Record updated
- 4 July 2025
Who can take part
- Age
- 18 years to 40 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 18 criteriaShow less
Who can take part
- Patients, both sexes, with symptomatic knee osteoarthritis with:
- Age: 18-40 years
- Unilateral involvement
- Signs and symptoms of knee osteoarthritis
- Radiographic or MRI signs of degenerative pathology of knee cartilage (Kellgren-Lawrence grade 1-3)
- Ability and consent of patients to actively participate in clinical follow-up
- Signature of informed consent
- Pain ≥ 4 on VAS s
Who cannot take part
- Patients undergoing intra-articular infiltration of other substance in the previous 6 months
- Patients undergoing knee surgery in the previous 12 months
- Patients abusing alcoholic beverages, drugs or medications
- Knee trauma treated in the previous 6 months
- Patients with malignant neoplasms
- Patients with rheumatic diseases
- Patients with uncontrolled metabolic diseases
- Patients with hematological diseases (coagulopathies)
- Other conditions that may interfere with the evaluation of OA treatment
- Patients unable to express consent
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Where in Italy
- IRCCS Istituto ortopedico RizzoliBologna, ItalyContact: Mirco Lo Presti, MDTaking people
About the trial
What the trial wants to find out
The study consists of 3 phases (enrollment, infiltrative procedure, and controls):
Read full original descriptionShow less
* Identification by specialized orthopedic medical staff belonging to the SC Orthopedic and Trauma Clinic II of the Rizzoli Orthopedic Institute of subjects who meet the study inclusion criteria. Signing of informed consent form and completion of evaluation questionnaires. * infiltrative procedure * Patients will be clinically evaluated before the infiltration procedure and at 1, 3, 6, and 12 months after treatment by trained medical personnel (outcome assessors). Questionnaires will be administered for clinical evaluations before treatment and at these clinical checkups during follow-up. Any adverse events to treatment will also be assessed during follow-up visits. The duration and extent of joint swelling and pain following infiltration will be reported, and any drug therapies taken by the patient will be recorded.
The group in the trial
- infiltrative procedureOther group
Treatment: PRP infiltration
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT06483269, who can take part
- Record updated
- 4 July 2025