The Innate Immune Response and Enteric Nervous System in Crohn's Disease.
Key facts
- Who runs it
- Aalborg University Hospital
- Where
- Denmark1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Terminated
- People taking part
- 12 people enrolled
- Started
- 4 Sept 2023
- Ended
- 1 Jun 2024
- Type of study
- Observational
- Treatments tested
- Immunohistochemistry
- Record updated
- 3 July 2024
- Why it stopped
- Preliminary results showed no signs of associations in the data.
Who can take part
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Histological preparations (tissue samples) from patients with Crohn's disease who have undergone bowel resection at Aalborg University Hospital in the period from 2012 to 2023
Who cannot take part
- If the tissue material does not include the ileocecal region
- If the pathology report does not indicate that there is tissue material from both inflamed and non-inflamed areas
- If the patient has registered a prohibition against research in the Tissue Utilization Registry
- The selection of cases starts with the most recent (by date) and stops when 25 suitable cases are found
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The study aims to explore the relationships between inflammation, nerve changes, and the expression of interferon-stimulated proteins in inflamed and non-inflamed bowel areas from patients with Crohn's disease. Crohn's disease is a chronic inflammatory condition with complex causes and mechanisms that remain uncertain despite extensive research.
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Methods and Procedures This exploratory study utilizes tissue samples from a clinical biobank at Aalborg University Hospital. The samples are paraffin-embedded blocks from which tissue sections are prepared for immunohistochemical and histological staining. The study focuses on assessing the expression of interferon-stimulated proteins through optimized immunohistochemical staining methods, ensuring reproducibility via automated machines. The protein expressions are then analyzed qualitatively and semi-quantitatively and compared with structural changes in the bowel tissues.
Treatments tested
- Immunohistochemistry
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Det medfødte Immunforsvar og Det Enteriske Nervesystem Ved Crohns Sygdom
- Record updated
- 3 July 2024