Vitamin A and D Supplementation in Allogeneic HCT

Prior treatment

• Repeated allogeneic transplantation of hematopoietic cells;

Other illness

• respiratory failure more than 1 degree. or oxygen dependence
• Uncontrolled bacterial or fungal infection at the time of inclusion, despite adequate antibacterial or antifungal therapy (CRP\>70 mg/l at the time of inclusion).

Lab values

• \- Severe organ failure: creatinine more than 2 norms; ALT, AST more than 5 norms; bilirubin more than 1.5 normal;
• Creatinine clearance below 60ml/min/1.73m2;
• Severe cardiac pathology, including a decrease in ejection fraction less than \<50%, unstable angina, exertional angina of III-IV functional class, heart failure of III-IV functional class, arrhythmia grade V according to Lawn

Other

• Unstable hemodynamics;
• Karnofsky index less than 70%
• Severe decrease in lung function, FEV1 \<50% or DLCO\<50% predicted
• Pregnancy
• Somatic or mental pathology that does not allow signing informed consent

• Diagnosis: acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, chronic myeloproliferative disease, chronic myeloid leukemia, lymphoblastic lymphoma, myeloma
• Standard disease risk: less than 5% clonal blasts in the bone marrow and the absence of blast forms in the peripheral blood at the time of inclusion in the study or at least partial response for lymphoproliferative neoplasms.
• Related compatible donor 10/10 HLA-matched or unrelated compatible donor 9-10/10 HLA-matched
• Age ≥18 years
• Absence of severe concomitant somatic diseases