Studying imaging and molecular markers of scarring in ulcerative colitis
Compares intestinal ultrasound and biopsy findings to detect scarring in adults with ulcerative colitis.
Plain-language title generated from the registry record
Registry title: Development of Novel Imaging and Molecular Biomarkers of Fibrosis in Patient With Ulcerative Colitis
Key facts
- Where
- Milan, ItalySee the site
Where in Italy
- IRCCS San Raffaele Hospital, MilanoMilan, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS San Raffaele
- Trial code
- NCT06516237
- Record updated
- 15 January 2026
- Original description
Prospective multicenter interventional non-randomized cross-sectional study. Ultrasound operators will be blinded to clinical and endoscopic findings and the endoscopist will be blinded of the clinical and ultrasound findings.Read full original descriptionShow less
Relationships Between Intestinal Ultrasound Parameters and Elastography Measurements With Histopathologic Findings in a Prospective Cohort of Patients With Ulcerative Colitis: Development of Novel Imaging and Molecular Biomarkers of Fibrosis
Prospective multicenter interventional non-randomized cross-sectional study. Ultrasound operators will be blinded to clinical and endoscopic findings and the endoscopist will be blinded of the clinical and ultrasound findings.
This study aims to develop novel imaging and molecular biomarkers of fibrosis, through the use of intestinal ultrasound and shear wave elastography, using histologic specimens obtained by endoscopic biopsies as reference standard.
Inclusion: Adult, 18 years of age and older,; Established diagnosis (> three months) of ulcerative colitis,; Performing colonoscopy, according to current standards of care and ECCO guidelines,; Ability to understand and comply with the study procedure and sign an informed consent form.
Exclusion: subjects who needs to change therapy; presence of ascites, active infections, any contraindication to colonoscopy (e.g. intolerance to preparation, severe flare),; poor quality of ultrasound imaging (due to luminal gas or body habitus), or a diagnosis of malignancy in the pathological specimen; Pregnancy,; inability to undergo intestinal ultrasound within the time set by the study,.