Ulcerative colitis trials in Italy

In Italy 49 Also abroad 382

49 trials · From ClinicalTrials.gov and EU CTIS (euclinicaltrials.eu), checked 10 November 2026. Ask the study team whether a trial fits you.

Phase 2Taking people
An Adaptive, Dose-Ranging, Phase 2 Study of Eltrekibart Given Alone or in Combination with Mirikizumab for the Treatment of Adult Patients with Moderately to Severely Active Ulcerative Colitis
Where
Bologna, Brescia, Fano, Florence, Messina, Milan, Modena, Monserrato, Padova, Pavia, Rome, Rozzano, San Donato Milanese, San Giovanni Rotondo, Turin
Age
18 years and over
People
593 worldwide
Run by
Eli Lilly & Co.
See details and how to join2023-507853-13-00 · EU 2023-507853-13-00
Phase 2Enrolling by invitation
Long-term Safety and Efficacy of Multiple Long-acting Antibodies Alone and in Combinations for IBD
Where
Bologna, Castellana Grotte, Legnano, Milan, Negrar, Padova, Pavia, Rome, Rozzano, San Donato Milanese, Turin
Age
18 years and over
People
645 worldwide
Run by
Spyre Therapeutics, Inc.
See details and how to joinNCT07652294 · EU 2025-524640-35-00
Phase 3Taking people
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
Where
Bologna, Castellana Grotte, Milan, Padova, Pisa, Rho, Roma, Rozzano
Age
18 years to 70 years
People
350 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT06937086 · EU 2024-520209-38-00
Phase 2Taking people
LY4268989 (MORF-057) Co-Administered With Mirikizumab in Adults With Moderately to Severely Active Ulcerative Colitis:
Where
Milan, Roma, Rozzano
Age
18 years to 80 years
People
252 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07186101
Phase 2Taking people
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
Where
Milan, Rho, Rome, Rozzano
Age
18 years to 80 years
People
1,431 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07415044
Phase 2Taking people
A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease
Where
Florence, Milan, Monza, Negrar, Rome, Rozzano
Age
18 years to 80 years
People
60 worldwide
Run by
Eli Lilly and Company
See details and how to joinNCT07483073 · EU 2025-524112-11-00
Phase 3Taking people
A Long-term Extension (LTE) Study of Guselkumab in Pediatric Participants
Where
Bergamo, Bologna, Rome, San Giovanni Rotondo, Trieste
Age
3 years to 64 years
People
196 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT06663332 · EU 2023-509560-16-00
Phase 3Taking people
A Study of JNJ-78934804 in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Milan, Negrar, Rome, Rozzano
Age
18 years and over
People
644 worldwide
Run by
Janssen Research & Development, LLC
See details and how to joinNCT07577856 · EU 2026-525923-26-00
Phase 4Taking people
A study to measure mirikizumab levels in breast milk of lactating participants receiving mirikizumab therapeutically for an approved indication
Where
Milan, Rho, Rome
People
16 worldwide
Run by
Eli Lilly & Co.
See details and how to join2025-522362-78-00 · EU 2025-522362-78-00
Phase 2Taking people
A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Where
Brescia, Milan, Negrar, Pavia, Rho, Rome, Rozzano, San Donato Milanese, Turin
Age
18 years and over
People
224 worldwide
Run by
Genentech, Inc.
See details and how to joinNCT06979336 · EU 2025-520690-39-00
Phase 2Taking people
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
Where
Bologna, Castellana Grotte, Legnano, Milan, Negrar, Padova, Pavia, Rome, Rozzano, San Donato Milanese, Turin
Age
18 years to 75 years
People
645 worldwide
Run by
Spyre Therapeutics, Inc.
See details and how to joinNCT07012395 · EU 2025-521242-26-00
Phase 3Taking people
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Where
Naples, Rome, San Giovanni Rotondo, Trieste
Age
2 years to 17 years
People
120 worldwide
Run by
AbbVie
See details and how to joinNCT07071519 · EU 2024-514695-41-00
Phase 3Taking people
A study evaluating the effects of filgotinib in children and teenagers with ulcerative colitis
Where
Alexandria, Ancona, Milan, Naples, Rome, Trieste
Age
Up to 17 years
People
68 worldwide
Run by
Alfasigma S.p.A.
See details and how to join2024-511458-32-00 · EU 2024-511458-32-00
No phaseTaking people
Multi-omics Dissection of Gut Microbiome Engraftment During FMT
Where
Rome
Age
18 years and over
People
90
Run by
Catholic University of the Sacred Heart
See details and how to joinNCT06992453
Phase 2Taking people
A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
Where
Bergamo, Florence, Milan, Naples
Age
2 years to 11 years
People
24 worldwide
Run by
Pfizer
See details and how to joinNCT07470879 · EU 2025-523100-77-00
Phase 3Taking people
An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Legnano, Milan
Age
16 years to 80 years
People
980 worldwide
Run by
Sanofi
See details and how to joinNCT07184996
Phase 2Taking people
A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
Where
Bologna, Milan, Rozzano
Age
18 years to 75 years
People
100 worldwide
Run by
Merck Sharp & Dohme LLC
See details and how to joinNCT07463183 · EU 2025-523479-49-00
Phase 2Taking people
A study of LY4268989 in participants with Moderately to Severely Active Ulcerative Colitis (EMERALD-3)
Where
Milan, Rho, Rome, Rozzano, San Donato Milanese
Age
18 years and over
People
104 worldwide
Run by
Eli Lilly & Co.
See details and how to join2025-524404-29-00 · EU 2025-524404-29-00
Phase 2Taking people
Confirmatory Clinical Study in Active Ulcerative Colitis
Where
Catanzaro, Legnano, Milan, Padova, Rome, Rozzano, San Donato Milanese
Age
16 years and over
People
204 worldwide
Run by
MRM Health NV
See details and how to joinNCT07296315 · EU 2025-524682-24-00
Phase 2Taking people
A Trial to Investigate PALI-2108 Versus Placebo in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Bari, Bologna, Matera, Negrar, Rome, Rozzano, San Giovanni Rotondo, Turin
Age
18 years to 75 years
People
204 worldwide
Run by
Palisade Bio
See details and how to joinNCT07845487
Phase 3Taking people
A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
Where
Alessandria, Ancona, Milan, Naples, Rome, Trieste
Age
8 years to 18 years
People
80 worldwide
Run by
Alfasigma S.p.A.
See details and how to joinNCT06865417
No phaseTaking people
Estimation of Cardiovascular Risk in Patients With Crohn's Disease and Ulcerative Colitis (PROVACI)
Where
San Donato Milanese
Age
16 years and over
People
600
Run by
IRCCS Policlinico S. Donato
See details and how to joinNCT07095634
Phase 3Taking people
A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis
Where
Rome, Rozzano, Turin
Age
16 years to 80 years
People
751 worldwide
Run by
Sanofi
See details and how to joinNCT07185009
Phase 3Taking people
A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)
Where
Messina, Milan, Pescara, Rome
Age
2 years to 17 years
People
70 worldwide
Run by
Takeda
See details and how to joinNCT06405087 · EU 2023-508804-39-00
Phase 2Taking people
LY4268989 (MORF-057) Co-Administered with Mirikizumab in Adults with Moderately to Severely Active Ulcerative Colitis: A Phase 2 Study
Where
Milan, Rome, Rozzano
Age
18 years and over
People
75 worldwide
Run by
Eli Lilly & Co.
See details and how to join2025-522338-30-00 · EU 2025-522338-30-00